Department of Thoracic Surgery, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Street, Guangzhou, Guangdong, People's Republic of China, 510000.
Department of Thoracic Surgery, Wuhan Union Hospital of Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, Hubei, People's Republic of China, 430022.
Arch Osteoporos. 2020 Mar 16;15(1):47. doi: 10.1007/s11657-020-00719-2.
Association between strength of nonadjacent muscles and bone mineral density is unclear. We used data from the National Health and Nutrition Examination Survey to convince the effect of grip strength on femoral neck and lumbar spine mineral density in the general US population. This research can broaden the area of muscle-bone interaction.
Grip test measures the maximum isotonic strength of hand and forearm and is often used as an indicator of general muscle strength. Muscle has been shown to exert positive effects on bone health, and studies are needed to test whether grip strength can be associated with bone mineral density of nonadjacent bones. The aim of this study is to assess whether grip strength is an independent predictor for bone mineral density (BMD) of femoral neck and total lumbar spine in the general US population.
We used the data from the National Health and Nutrition Examination Survey (NHANES) 2013-2014, and 1850 participants aged from 40 to 80 years old were included in the analysis. Grip strength was recorded as the largest reading of three efforts of one's dominant hand using a handgrip dynamometer. Femoral neck and lumbar spine BMDs were measured through Dual-energy X-ray absorptiometry (DXA) scan. Univariate and multivariate linear regression analyses were done to examine the association between grip strength and BMDs.
After adjusting for age, ethnicity, body mass index (BMI), use of female hormones, smoking habit, drinking habit, family history of osteoporosis, use of calcium and vitamin D supplements, physical activity, serum calcium, and phosphorus levels, grip strength is associated with increased femoral neck and total lumbar spine BMDs in men (P < 0.001, P = 0.005), premenopausal women (P = 0.040, P = 0.014), and postmenopausal women (P = 0.016, P = 0.012).
Our results suggest that (1) grip strength can be associated with BMD of nonadjacent bones, and (2) grip strength of dominant hand can be an indicator of BMD in the general US population across genders and menopausal status.
使用来自国家健康和营养检查调查（NHANES）2013-2014 年的数据，评估握力是否是普通美国人群股骨颈和总腰椎骨矿物质密度（BMD）的独立预测因子。
我们分析了 1850 名 40-80 岁的参与者的数据。使用握力计记录握力，记录最大读数的三次努力。通过双能 X 线吸收法（DXA）扫描测量股骨颈和腰椎 BMD。进行单变量和多变量线性回归分析，以检查握力与 BMD 之间的关系。
调整年龄、种族、体重指数（BMI）、女性激素使用、吸烟习惯、饮酒习惯、骨质疏松家族史、钙和维生素 D 补充剂使用、身体活动、血清钙和磷水平后，握力与男性（P<0.001，P=0.005）、绝经前妇女（P=0.040，P=0.014）和绝经后妇女（P=0.016，P=0.012）的股骨颈和总腰椎 BMD 增加相关。
我们的结果表明，（1）握力与非相邻骨骼的 BMD 相关，（2）优势手的握力可以作为普通美国人群在性别和绝经状态下 BMD 的指标。
