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银纳米颗粒对肺癌细胞的抗侵袭性与尺寸相关。

Size dependent anti-invasiveness of silver nanoparticles in lung cancer cells.

作者信息

Que Yu Mei, Fan Xiao Qing, Lin Xiao Juan, Jiang Xiao Li, Hu Ping Ping, Tong Xiao Yong, Tan Qun You

机构信息

Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University Chongqing 401331 PR China

Department of Thoracic Surgery, Institute of Surgery Research, Daping Hospital, Army Medical University Chongqing 400042 P. R. China

出版信息

RSC Adv. 2019 Jul 5;9(37):21134-21138. doi: 10.1039/c9ra03662h.

DOI:10.1039/c9ra03662h
PMID:35521328
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9066013/
Abstract

The molecular mechanism of cancer cell death caused by silver nanoparticles (AgNPs) of different sizes is investigated. Compared with the larger nanoparticles, 13 nm AgNPs significantly inhibit the migration and invasiveness of lung adenocarcinoma A549 cells, induce elevated reactive oxygen species and lead to NF-κB directed cellular apoptosis.

摘要

研究了不同尺寸的银纳米颗粒（AgNPs）导致癌细胞死亡的分子机制。与较大的纳米颗粒相比，13纳米的AgNPs显著抑制肺腺癌A549细胞的迁移和侵袭能力，诱导活性氧水平升高并导致NF-κB介导的细胞凋亡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9515/9066013/ba41e63a96a7/c9ra03662h-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9515/9066013/67f9e2d1971e/c9ra03662h-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9515/9066013/6b1cd2edb325/c9ra03662h-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9515/9066013/f148d7937f7d/c9ra03662h-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9515/9066013/1e50577c7bbe/c9ra03662h-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9515/9066013/da211a750e57/c9ra03662h-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9515/9066013/ba41e63a96a7/c9ra03662h-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9515/9066013/67f9e2d1971e/c9ra03662h-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9515/9066013/6b1cd2edb325/c9ra03662h-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9515/9066013/f148d7937f7d/c9ra03662h-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9515/9066013/1e50577c7bbe/c9ra03662h-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9515/9066013/da211a750e57/c9ra03662h-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9515/9066013/ba41e63a96a7/c9ra03662h-f6.jpg

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Chem Commun (Camb). 2019 Jun 11;55(48):6890-6893. doi: 10.1039/c9cc02415h.
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