银纳米颗粒对肺癌细胞的抗侵袭性与尺寸相关。

Size dependent anti-invasiveness of silver nanoparticles in lung cancer cells.

作者信息

Que Yu Mei, Fan Xiao Qing, Lin Xiao Juan, Jiang Xiao Li, Hu Ping Ping, Tong Xiao Yong, Tan Qun You

机构信息

Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University Chongqing 401331 PR China

Department of Thoracic Surgery, Institute of Surgery Research, Daping Hospital, Army Medical University Chongqing 400042 P. R. China

出版信息

RSC Adv. 2019 Jul 5;9(37):21134-21138. doi: 10.1039/c9ra03662h.

The molecular mechanism of cancer cell death caused by silver nanoparticles (AgNPs) of different sizes is investigated. Compared with the larger nanoparticles, 13 nm AgNPs significantly inhibit the migration and invasiveness of lung adenocarcinoma A549 cells, induce elevated reactive oxygen species and lead to NF-κB directed cellular apoptosis.