Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Amplyx Pharmaceuticals, San Diego, California, USA.
Antimicrob Agents Chemother. 2020 Apr 21;64(5). doi: 10.1128/AAC.00261-20.
Manogepix is a broad-spectrum antifungal agent that inhibits glycosylphosphatidylinositol (GPI) anchor biosynthesis. Using whole-genome sequencing, we characterized two efflux-mediated mechanisms in the fungal pathogens and that resulted in decreased manogepix susceptibility. In , a gain-of-function mutation in the transcription factor gene activated expression of ATP-binding cassette transporter genes and In , a mitochondrial deletion activated expression of the major facilitator superfamily transporter gene .
马尼格匹克斯是一种广谱抗真菌药物，可抑制糖基磷脂酰肌醇（GPI）锚定生物合成。我们通过全基因组测序，鉴定了真菌病原体 和 中两种与外排相关的机制，导致马尼格匹克斯敏感性降低。在 中，转录因子基因 的功能获得性突变激活了 ATP 结合盒转运蛋白基因 和 的表达。在 中，线粒体缺失激活了主要易化因子超家族转运蛋白基因 的表达。
