From the Department of Family Medicine, University of Iowa Carver College of Medicine, Iowa City, IA (PK, JMD, MAB-S, MES, BTL); Department of Epidemiology, University of Iowa College of Public Health, Iowa City, IA (BTL); Oregon Rural Practice-based Research Network, Oregon Health & Science University, Portland, OR (LCM); Department of Medical Informatics and Clinical Epidemiology, Oregon Health and Science University, Portland, OR (DAD).
J Am Board Fam Med. 2020 Mar-Apr;33(2):322-338. doi: 10.3122/jabfm.2020.02.190173.
Patient identification is an important step for advance care planning (ACP) discussions.
We conducted a scoping review to identify prognostic indices potentially useful for initiating ACP.
We included studies that developed and/or validated a multivariable prognostic index for all-cause mortality between 6 months and 5 years in community-dwelling adults. PubMed was searched in October 2018 for articles meeting our search criteria. If a systematic review was identified from the search, we checked for additional eligible articles in its references. We abstracted data on population studied, discrimination, calibration, where to find the index, and variables included. Each index was further assessed for clinical usability.
We identified 18 articles with a total of 17 unique prognostic indices after screening 9154 titles. The majority of indices (88%) had c-statistics greater than or equal to 0.70. Only 1 index was externally validated. Ten indices, 8 developed in the United States and 2 in the United Kingdom, were considered clinically usable.
Of the 17 unique prognostic indices, 10 may be useful for implementation in the primary care setting to identify patients who may benefit from ACP discussions. An index classified as "clinically usable" may not be easy to use because of a large number of variables that are not routinely collected and the need to program the index into the electronic medical record.
患者识别是预先医疗照护计划(ACP)讨论的重要步骤。
我们进行了范围性回顾,以确定可能对启动 ACP 有用的预后指标。
我们纳入了开发和/或验证了 6 个月至 5 年内社区居住成年人全因死亡率的多变量预后指标的研究。2018 年 10 月,我们在 PubMed 上搜索符合我们检索标准的文章。如果从搜索中确定了系统评价,我们会检查其参考文献中是否有其他符合条件的文章。我们提取了研究人群、区分度、校准度、在哪里可以找到指标以及纳入的变量等数据。每个指标都进一步评估了其临床可用性。
经过筛选 9154 篇标题后,我们确定了 18 篇文章,共 17 个独特的预后指标。大多数指标(88%)的 c 统计量大于或等于 0.70。只有 1 个指标经过外部验证。10 个指标中有 8 个在美国开发,2 个在英国开发,被认为具有临床可用性。
在 17 个独特的预后指标中,有 10 个可能有助于在初级保健环境中实施,以确定可能从 ACP 讨论中受益的患者。被归类为“临床可用”的指标可能由于变量数量大且不易收集,以及需要将其编入电子病历,而不易使用。