Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Sci Rep. 2020 Mar 16;10(1):4767. doi: 10.1038/s41598-020-61759-9.
Reduced pancreas volume, as measured by non-contrast magnetic resonance imaging (MRI), is observed in individuals with newly-diagnosed type 1 diabetes (T1D) and declines over the first year after diagnosis. In this study, we determined the repeatability and inter-reader reproducibility of pancreas volume measurements by MRI. Test-retest scans in individuals with or without T1D (n = 16) had an intraclass correlation coefficient (ICC) of 0.985 (95% CI 0.961 to 0.995) for pancreas volume. Independent pancreas outlines by two board-certified radiologists (n = 30) yielded an ICC of 0.945 (95% CI 0.889 to 0.973). The mean Dice coefficient, a measurement of the degree of overlap between pancreas regions of interest between the two readers, was 0.77. Prandial state did not influence pancreatic measurements, as stomach volume did not correlate with pancreas volume. These data demonstrate that MRI measurements of pancreas volume between two readers are repeatable and reproducible with ICCs that correspond to excellent clinical significance (ICC > 0.9), are not related to changes in stomach volume, and could be a useful tool for clinical investigation of diabetes and other pancreas pathologies.
胰腺体积减小，通过非对比磁共振成像（MRI）测量，在新诊断的 1 型糖尿病（T1D）患者中观察到，并且在诊断后第一年下降。在这项研究中，我们确定了 MRI 测量胰腺体积的重复性和读者间可重复性。有或没有 T1D 的个体的测试-重测扫描（n=16）的胰腺体积的组内相关系数（ICC）为 0.985（95%置信区间 0.961 至 0.995）。两位经过董事会认证的放射科医生的独立胰腺轮廓（n=30）的 ICC 为 0.945（95%置信区间 0.889 至 0.973）。两个读者之间的感兴趣胰腺区域之间重叠程度的平均骰子系数为 0.77。进餐状态不会影响胰腺测量，因为胃体积与胰腺体积不相关。这些数据表明，MRI 测量两个读者之间的胰腺体积具有重复性和可重复性，ICC 对应于极好的临床意义（ICC>0.9），与胃体积的变化无关，并且可能是糖尿病和其他胰腺病理学临床研究的有用工具。
