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葡萄籽提取物:具有潜在的健康益处。

Grape seed extract: having a potential health benefits.

作者信息

Gupta Madhavi, Dey Sanjay, Marbaniang Daphisha, Pal Paulami, Ray Subhabrata, Mazumder Bhaskar

机构信息

1Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam India.

Division of Pharmaceutics, Calcutta Institute of Pharmaceutical Technology and Allied Health Sciences, Banitabla, Ulberia, Howrah, West Bengal India.

出版信息

J Food Sci Technol. 2020 Apr;57(4):1205-1215. doi: 10.1007/s13197-019-04113-w. Epub 2019 Sep 30.

DOI:10.1007/s13197-019-04113-w
PMID:32180617
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7054588/
Abstract

Grapes are one of the most highly consumed fruits across the world. In ancient Europe the leaves and the sap of grape plants has been used in traditional treatment for ages. Besides being a wellspring for vitamins and fibre, the skin and seeds of grapes are highly rich in Polyphenols specifically proanthocyanidins, which can be used as a functional ingredient to address various health issues by boosting the natural bio-processes of the body. Since, grape seeds are by product of wine making companies therefore can be easily procured. The present review article briefly describes the various pharmacological activities of grape seed extract and different experimental studies were done which supports the beneficial health qualities of the extract. Through different and various studies, it was proved that the proanthocyanidin rich grape seed extract provides benefits against many diseases i.e. inflammation, cardiovascular disease, hypertension, diabetes, cancer, peptic ulcer, microbial infections, etc. Therefore, beside from using it as a nutraceutical or cosmeceutical, as a result they may have a potential to substitute or complement in currently used drugs in the treatment of diseases by developing it into other successful pharmaceutical formulations for better future prospective.

摘要

葡萄是全球消费率最高的水果之一。在古代欧洲,葡萄植株的叶子和汁液长期以来一直被用于传统治疗。葡萄不仅是维生素和纤维的来源,其果皮和种子还富含多酚类物质,特别是原花青素,可作为功能性成分,通过促进人体自然生物过程来解决各种健康问题。由于葡萄籽是酿酒公司的副产品,因此很容易获得。本综述文章简要描述了葡萄籽提取物的各种药理活性,并进行了不同的实验研究,这些研究支持了该提取物有益健康的特性。通过各种不同的研究证明,富含原花青素的葡萄籽提取物对许多疾病都有好处,如炎症、心血管疾病、高血压、糖尿病、癌症、消化性溃疡、微生物感染等。因此,除了将其用作营养保健品或美容化妆品外,它们还有可能通过开发成其他成功的药物制剂,在治疗疾病方面替代或补充目前使用的药物,从而拥有更好的未来前景。

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Is there a role for lifestyle changes in cardiovascular prevention? What, when and how?生活方式的改变在心血管疾病预防中能起到作用吗?是什么作用、何时起作用以及如何起作用?
Atheroscler Suppl. 2017 Apr;26:2-15. doi: 10.1016/S1567-5688(17)30020-X.
3
The impact of grape seed extract treatment on blood pressure changes: A meta-analysis of 16 randomized controlled trials.葡萄籽提取物治疗对血压变化的影响:16项随机对照试验的荟萃分析。
Medicine (Baltimore). 2016 Aug;95(33):e4247. doi: 10.1097/MD.0000000000004247.
4
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J Geriatr Cardiol. 2015 Jul;12(4):417-23. doi: 10.11909/j.issn.1671-5411.2015.04.014.
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Wine grape pomace flour improves blood pressure, fasting glucose and protein damage in humans: a randomized controlled trial.酿酒葡萄果渣粉可改善人体血压、空腹血糖和蛋白质损伤:一项随机对照试验。
Biol Res. 2015 Sep 4;48(1):49. doi: 10.1186/s40659-015-0040-9.
6
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