Hirsa Mikołaj, Fichna Jakub, Tarasiuk-Zawadzka Aleksandra
Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Mazowiecka 5, Lodz, 92-215, Poland.
Curr Nutr Rep. 2025 Aug 11;14(1):100. doi: 10.1007/s13668-025-00695-4.
This narrative review aims to explore the anti-inflammatory potential of fruit seed extracts, emphasizing their bioactive components such as antioxidants, polyphenols, fatty acids, vitamins, and minerals. By examining studies published from 1993 to 2024, it evaluates how these natural compounds may contribute to reducing inflammation and oxidative stress.
Recent literature indicates a strong correlation between the intake of fruit and vegetable-based compounds and reduced inflammatory markers. In contrast, diets high in sugars, saturated fats, and additives are linked with heightened inflammatory responses. Several fruit seed extracts demonstrate notable anti-inflammatory, antioxidant, and anticancer properties, largely attributed to their high concentrations of polyphenols and other phytochemicals. Fruit seed extracts contain bioactive compounds that modulate key inflammatory signaling pathways, such as NF-κB and MAPK, and exhibit strong antioxidant properties. These mechanisms contribute to their potential use as natural therapeutic agents for managing chronic inflammatory conditions, including cardiovascular disease, arthritis, and metabolic disorders. Future research should focus on clinical validation, standardization of extract formulations, and understanding long-term safety and efficacy in human populations.
本叙述性综述旨在探讨水果种子提取物的抗炎潜力，重点关注其生物活性成分，如抗氧化剂、多酚、脂肪酸、维生素和矿物质。通过研究1993年至2024年发表的文献，评估这些天然化合物如何有助于减轻炎症和氧化应激。
近期文献表明，摄入基于水果和蔬菜的化合物与炎症标志物降低之间存在密切关联。相反，高糖、饱和脂肪和添加剂的饮食与炎症反应加剧有关。几种水果种子提取物表现出显著的抗炎、抗氧化和抗癌特性，这主要归因于它们富含多酚和其他植物化学物质。水果种子提取物含有可调节关键炎症信号通路（如NF-κB和MAPK）的生物活性化合物，并具有强大的抗氧化特性。这些机制有助于它们作为天然治疗剂用于管理慢性炎症性疾病，包括心血管疾病、关节炎和代谢紊乱。未来的研究应侧重于临床验证、提取物配方的标准化以及了解其在人群中的长期安全性和有效性。
