Bour James R, Wright Ashley M, He Xin, Dincă Mircea
Department of Chemistry , Massachusetts Institute of Technology , 77 Massachusetts Avenue , Cambridge , Massachusetts 02139 , USA . Email:
Chem Sci. 2020 Jan 23;11(7):1728-1737. doi: 10.1039/c9sc06418d. eCollection 2020 Feb 21.
The secondary building units (SBUs) in metal-organic frameworks (MOFs) support metal ions in well-defined and site-isolated coordination environments with ligand fields similar to those found in metalloenzymes. This burgeoning class of materials has accordingly been recognized as an attractive platform for metalloenzyme active site mimicry and biomimetic catalysis. Early progress in this area was slowed by challenges such as a limited range of hydrolytic stability and a relatively poor diversity of redox-active metals that could be incorporated into SBUs. However, recent progress with water-stable MOFs and the development of more sophisticated synthetic routes such as postsynthetic cation exchange have largely addressed these challenges. MOF SBUs are being leveraged to interrogate traditionally unstable intermediates and catalytic processes involving small gaseous molecules. This perspective describes recent advances in the use of metal centers within SBUs for biomimetic chemistry and discusses key future developments in this area.
金属有机框架（MOF）中的二级建筑单元（SBU）在定义明确且位点隔离的配位环境中支撑金属离子，其配体场与金属酶中的类似。因此，这类新兴材料被认为是用于模拟金属酶活性位点和进行仿生催化的有吸引力的平台。该领域的早期进展因诸如水解稳定性范围有限以及可纳入SBU的氧化还原活性金属多样性相对较差等挑战而放缓。然而，水稳定MOF的最新进展以及诸如后合成阳离子交换等更复杂合成路线的发展在很大程度上解决了这些挑战。MOF SBU正被用于研究传统上不稳定的中间体以及涉及小分子气体的催化过程。本综述描述了在SBU中使用金属中心进行仿生化学的最新进展，并讨论了该领域未来的关键发展。
