Tewatia Pavit, Kaushik Rajeev Mohan, Kaushik Reshma, Kumar Sanjeev
Department of General Medicine, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, P.O. Jolly Grant- 248016, Dehradun, Uttarakhand, India.
Department of Pulmonary Medicine, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, P.O. Jolly Grant- 248016, Dehradun, Uttarakhand, India.
Glob Health Epidemiol Genom. 2020 Feb 12;5:e1. doi: 10.1017/gheg.2020.1.
This study assessed the tobacco smoking-associated risk for tuberculous pleural effusion (TPE) in India. Ninety-two patients with TPE and 184 controls were randomly selected and assessed regarding their tobacco-smoking status and type, quantity and duration of tobacco used. Odds ratios (ORs) for the association of smoking cigarette, beedi and cigarette or beedi with TPE were 19.22 ( < 0.0001), 2.89 ( = 0.0006) and 4.57 ( < 0.0001) respectively. ORs for developing TPE increased with an increase in beedi/cigarette consumption, duration and pack years of smoking ( < 0.001 each). TPE was significantly associated with confounding risk factors viz., regular alcohol use (OR = 1.89, = 0.019), history of contact with tuberculosis (TB) patient (OR = 8.07, < 0.0001), past history of TB (OR = 22.31, < 0.0001), family history of TB (OR = 9.05, = 0.0002) and underweight (OR = 3.73, = 0.0009). Smoking (OR = 3.07, < 0.001), regular alcohol use (OR = 2.10, = 0.018), history of contact with TB patient (OR = 4.01, = 0.040), family history of TB (OR = 10.80, = 0.001) and underweight (OR = 5.04, < 0.001) were independently associated with TPE. Thus, both cigarette- and beedi-smoking have a significant association with TPE. The risk for TPE in tobacco smokers is dose- and duration-dependent.
本研究评估了印度吸烟与结核性胸腔积液（TPE）的相关风险。随机选取了92例TPE患者和184例对照，评估他们的吸烟状况、烟草类型、使用量和使用时长。吸烟、抽比迪烟以及既吸烟又抽比迪烟与TPE关联的比值比（OR）分别为19.22（<0.0001）、2.89（=0.0006）和4.57（<0.0001）。发生TPE的OR随着比迪烟/香烟消费量、使用时长和吸烟包年数的增加而升高（每项均<0.001）。TPE与混杂风险因素显著相关，即经常饮酒（OR=1.89，=0.019）、接触过结核病（TB）患者史（OR=8.07，<0.0001）、既往TB病史（OR=22.31，<0.0001）、TB家族史（OR=9.05，=0.0002）和体重过轻（OR=3.73，=0.0009）。吸烟（OR=3.07，<0.001）、经常饮酒（OR=2.10，=0.018）、接触TB患者史（OR=4.01，=0.040）、TB家族史（OR=10.80，=0.001）和体重过轻（OR=5.04，<0.001）均与TPE独立相关。因此，吸烟和抽比迪烟均与TPE显著相关。吸烟者发生TPE的风险呈剂量和时长依赖性。
