当归中环庚三烯酚酮和土木香烷型生物碱的细胞毒性活性。
Cytotoxic Activity of Inositol Angelates and Tirucallane-Type Alkaloids from .
机构信息
Zhejiang Provincial Key Laboratory of Chemical Utilization of Forestry Biomass, Zhejiang A&F University, Lin'an 311300, Zhejiang, China.
College of Plant Science, Jilin University, Xi'an Road No. 5333, Changchun 130062, Jilin, China.
出版信息
Molecules. 2020 Mar 9;25(5):1222. doi: 10.3390/molecules25051222.
Three new inositol angelate compounds () and two new tirucallane-type alkaloids ( and ) were isolated from the , and their structures were established mainly by means of combination of 1D and 2D nuclear magnetic resonance and HR-ESI-MS. Based on cytotoxicity testing, compounds and exhibited significant cytotoxic activity against human cancer cell line HepG2 with IC value at 8.4 and 13.2 μM. In addition, compounds and also showed remarkable growth inhibitory activity to larvae.
从 中分离得到 3 个新的肌醇当归酸盐化合物 () 和 2 个新的羽扇豆烷型生物碱 ( 和 )，其结构主要通过 1D 和 2D 核磁共振和 HR-ESI-MS 相结合来确定。基于细胞毒性测试，化合物 和 对 HepG2 人癌细胞系表现出显著的细胞毒性，IC 值分别为 8.4 和 13.2 μM。此外，化合物 和 对 幼虫也表现出显著的生长抑制活性。
Zotero 插件