Pearson Wendy, Guazzelli Pezzali Julia, Antunes Donadelli Renan, Wagner Ashley, Buff Preston
Department of Animal Biosciences, University of Guelph, Guelph, ON N1G 2W1, Canada.
Probiotech International, Saint-Hyacinthe, QC J2S 8L2, Canada.
Animals (Basel). 2020 Mar 13;10(3):486. doi: 10.3390/ani10030486.
There is little information available to describe the inflammatory consequences of and recovery from moderate-intensity exercise bouts in hunting dogs. The purpose of the current study is to generate pilot data on the appearance and disappearance of biomarkers of inflammation and inflammation resolution following a typical one-hour exercise bout in basset hounds. Four hounds were set out to find a scent and freely adopted running or walking over wooded terrain for approximately one hour. Venous blood samples were obtained before the exercise and at 1, 2, 4, 6, and 10 hours following cessation of exercise and were analyzed for biomarkers of inflammation (prostaglandin E (PGE), nitric oxide (NO), interleukin 1β (IL-1β)) tumour necrosis factor-α (TNF-α)), and inflammation resolution (resolvin D1 (RvD1)). There was an increase in inflammation one hour after the exercise, shown by a significant increase in PGE. Following this peak, PGE steadily declined at the same time as RvD1 increased, with RvD1 peaking at six hours. This pilot study provides evidence that dogs that undergo an hour of hunt exercise experience transient inflammation that peaks one hour after the end of exercise; inflammation resolution peaks six hours after the end of exercise. Future studies should seek to further understand the distinct and combined roles of PGE and RvD1 in dog adaptation to exercise stress.
目前几乎没有信息可用于描述猎犬进行中等强度运动后的炎症后果及恢复情况。本研究的目的是获取有关巴吉度猎犬在进行典型的一小时运动后炎症生物标志物的出现和消失以及炎症消退情况的初步数据。让四只猎犬去追踪一种气味，并在树木繁茂的地形上自由地奔跑或行走大约一小时。在运动前以及运动停止后的1、2、4、6和10小时采集静脉血样，分析炎症生物标志物（前列腺素E（PGE）、一氧化氮（NO）、白细胞介素1β（IL-1β）、肿瘤坏死因子-α（TNF-α））以及炎症消退生物标志物（消退素D1（RvD1））。运动一小时后炎症增加，表现为PGE显著升高。在达到这个峰值后，PGE稳步下降，同时RvD1升高，RvD1在6小时达到峰值。这项初步研究提供了证据，表明经历一小时狩猎运动的犬会经历短暂炎症，在运动结束后1小时达到峰值；炎症消退在运动结束后6小时达到峰值。未来的研究应进一步了解PGE和RvD1在犬适应运动应激中的独特作用及联合作用。
