Hospital of Stomatology, Jilin University, Changchun 130021, China.
Department of Pharmacy, The First Hospital of Jilin University, Changchun 130021, China.
Int J Environ Res Public Health. 2020 Mar 14;17(6):1887. doi: 10.3390/ijerph17061887.
Oral mucosal disease (OMD) is a public health challenge globally, but the epidemiological findings in older adults have been inconsistent in China. Thus, this meta-analysis was carried out to explore the prevalence of OMD and its moderating factors in this population. An electronic literature search was conducted of both international (PubMed, PsycINFO, and EMBASE) and Chinese (China National Knowledge Infrastructure and WanFang) databases from inception to November 1, 2019. The Der-Simonian and Laird random effects model was used to synthesize the prevalence of OMD and its 95% confidence intervals (95% CI). Twenty-four studies covering 23,653 older adults were included. The pooled prevalence of OMD was 23% (95% confidence interval: 17.9%-29.0%) Subgroup analyses and meta-analysis revealed that the prevalence of OMD was significantly associated with the reporting sampling, year of publication, and survey (all values <0.05). This meta-analysis found that the prevalence of OMD among older adults in mainland China was significantly high. Early detection and effective intervention of OMD in older adults have public health and clinical importance.
口腔黏膜疾病（OMD）是全球性的公共卫生挑战，但中国老年人的流行病学研究结果并不一致。因此，进行了这项荟萃分析，以探讨该人群中 OMD 的患病率及其调节因素。从开始到 2019 年 11 月 1 日，对国际（PubMed、PsycINFO 和 EMBASE）和中文（中国国家知识基础设施和万方）数据库进行了电子文献检索。使用 Der-Simonian 和 Laird 随机效应模型来综合 OMD 的患病率及其 95%置信区间（95%CI）。纳入了 24 项涵盖 23653 名老年人的研究。OMD 的总患病率为 23%（95%置信区间：17.9%-29.0%）。亚组分析和荟萃分析表明，OMD 的患病率与报告抽样、发表年份和调查显著相关（所有 值<0.05）。这项荟萃分析发现，中国大陆老年人中 OMD 的患病率显著较高。早期发现和有效干预老年人的 OMD 具有公共卫生和临床重要性。
