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一条通向学术药物研发的奇特线性路径。

A Curiously Linear Path to Academic Drug Discovery.

作者信息

Nelson Kathryn M

机构信息

Department of Medicinal Chemistry, Institute for Therapeutics Discovery and Development, University of Minnesota, Minneapolis, Minnesota 55414, United States.

出版信息

ACS Med Chem Lett. 2020 Mar 12;11(3):217-220. doi: 10.1021/acsmedchemlett.9b00459.

DOI:10.1021/acsmedchemlett.9b00459
PMID:32184945
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7073868/
Abstract

Medicinal chemistry graduate students interested in drug discovery usually consider only two career paths: become a tenure track principal investigator of a lab with a focused research interest, or become an industry scientist at a pharmaceutical company. This Viewpoint article will highlight a unique career path that is neither of these and is a new model, involving collaboration, creative problem solving, and a willingness to learn new things, that perhaps can prove successful for others.

摘要

对药物研发感兴趣的药物化学研究生通常只考虑两条职业道路

成为一名专注于特定研究兴趣的实验室终身教职的首席研究员,或者成为一家制药公司的行业科学家。这篇观点文章将重点介绍一条独特的职业道路,它不属于上述任何一种,而是一种新模式,涉及合作、创造性地解决问题以及愿意学习新事物,或许对其他人来说也能证明是成功的。

相似文献

1
A Curiously Linear Path to Academic Drug Discovery.一条通向学术药物研发的奇特线性路径。
ACS Med Chem Lett. 2020 Mar 12;11(3):217-220. doi: 10.1021/acsmedchemlett.9b00459.
2
Evaluation of a Medical Student Research and Career Development Program to Increase Diversity in Academic Medicine.评估医学生研究和职业发展计划,以增加学术医学的多样性。
Acad Med. 2019 Aug;94(8):1220-1228. doi: 10.1097/ACM.0000000000002760.
3
The declining interest in an academic career.对学术生涯兴趣的下降。
PLoS One. 2017 Sep 18;12(9):e0184130. doi: 10.1371/journal.pone.0184130. eCollection 2017.
4
[Early achievements of the Danish pharmaceutical industry--8. Lundbeck].[丹麦制药行业的早期成就——8. 灵北公司]
Theriaca. 2016(43):9-61.
5
Legal and ethical obligations to conduct a clinical drug trial in Australia as an investigator initiated and sponsored study for an overseas pharmaceutical company.作为一项由海外制药公司发起并赞助的研究者发起的研究,在澳大利亚开展临床药物试验的法律和伦理义务。
Med Law. 2004;23(4):913-24.
6
The Transition from Academia: Overcoming the Barrier to a Career in the Drug Discovery Industry.从学术界转型:克服进入药物发现行业的障碍。
J Chem Inf Model. 2018 Jun 25;58(6):1161-1163. doi: 10.1021/acs.jcim.8b00262. Epub 2018 May 18.
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Challenges facing physician scientist trainees: a survey of trainees in Canada's largest undergraduate and postgraduate programs in a single centre.医师科学家培训生面临的挑战:对加拿大单一中心最大的本科和研究生项目中的培训生进行的一项调查。
Clin Invest Med. 2014 Oct 4;37(5):E268-83. doi: 10.25011/cim.v37i5.22008.
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Training Future Dentists for an Academic Career: A Three-Tiered Model.为学术生涯培养未来牙医:一种三层模式。
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Exploring intentions of physician-scientist trainees: factors influencing MD and MD/PhD interest in research careers.探索医学科学家培训生的意向:影响医学博士和医学博士/哲学博士对科研职业兴趣的因素。
BMC Med Educ. 2017 Jul 11;17(1):115. doi: 10.1186/s12909-017-0954-8.
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CBE Life Sci Educ. 2019 Jun;18(2):ar20. doi: 10.1187/cbe.18-09-0199.

本文引用的文献

1
Are academic drug discovery efforts receiving more recognition with declining industry efficiency?随着制药行业效率的下降,学术性药物研发工作是否得到了更多认可?
Expert Opin Drug Discov. 2019 Jul;14(7):605-607. doi: 10.1080/17460441.2019.1596080. Epub 2019 Mar 26.
2
Intranasal Coadministration of a Diazepam Prodrug with a Converting Enzyme Results in Rapid Absorption of Diazepam in Rats.鼻腔内给予地西泮前药与转化酶共给药可使大鼠快速吸收地西泮。
J Pharmacol Exp Ther. 2019 Sep;370(3):796-805. doi: 10.1124/jpet.118.255943. Epub 2019 Mar 5.
3
The changing career trajectories of new parents in STEM.新父母在 STEM 领域职业轨迹的变化。
Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4182-4187. doi: 10.1073/pnas.1810862116. Epub 2019 Feb 19.
4
Medicinal Chemistry: Where Are All the Women?药物化学:女性都在哪里?
ACS Med Chem Lett. 2017 Aug 25;8(9):900-902. doi: 10.1021/acsmedchemlett.7b00321. eCollection 2017 Sep 14.
5
The Essential Medicinal Chemistry of Curcumin.姜黄素的基础药物化学
J Med Chem. 2017 Mar 9;60(5):1620-1637. doi: 10.1021/acs.jmedchem.6b00975. Epub 2017 Jan 11.
6
Drug discovery goes back to school: changing ecosystem of drug discovery and the rising role of academia.药物研发回归校园:药物研发生态系统的变革与学术界日益重要的作用。
J Peripher Nerv Syst. 2014 Oct;19 Suppl 2:S2-4. doi: 10.1111/jns.12079_1.
7
The Innovation Forager: stimulating academic innovation.创新探索者:激发学术创新。
Acad Med. 2014 Feb;89(2):194. doi: 10.1097/ACM.0000000000000119.
8
From HTS to Phase I: the Institute for Therapeutics Discovery and Development at the University of Minnesota.从高通量筛选到一期临床试验:明尼苏达大学治疗学发现与开发研究所
Comb Chem High Throughput Screen. 2014 Mar;17(3):231-40. doi: 10.2174/1386207317666140109122033.
9
Bringing together the academic drug discovery community.汇聚学术药物研发界。
Nat Rev Drug Discov. 2013 Nov;12(11):811-2. doi: 10.1038/nrd4155.
10
The emerging academic drug-discovery sector.新兴的学术药物研发领域。
Future Med Chem. 2009 Sep;1(6):1013-7. doi: 10.4155/fmc.09.78.