Klietz M, Schnur T, Drexel S, Lange F, Tulke A, Rippena L, Paracka L, Dressler D, Höglinger G U, Wegner F
Department of Neurology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany.
Behavioral Engineering Research Group, KU Leuven, Naamsestraat 69, 3000 Leuven, Belgium.
Parkinsons Dis. 2020 Feb 24;2020:5184084. doi: 10.1155/2020/5184084. eCollection 2020.
Parkinson's disease (PD) is a chronic progressive movement disorder with severe reduction in patients' health-related quality of life (HR-QoL). Motor and cognitive symptoms are especially linked with decreased PD patients' HR-QoL. However, the relationship of these symptoms to caregiver burden is relatively unclear. Influence of the Montreal Cognitive Assessment scale (MoCA) as a cognitive screening tool and Movement Disorders Society Unified Parkinson's disease Rating Scale MDS-UPDRS symptoms in relation to patients' HR-QoL and caregivers` burden was analyzed. PD patients ( = 124) completed MDS-UPDRS, MoCA, and the PD questionnaire 8 (PDQ-8) as a measure of quality of life. Caregivers ( = 78) were assessed by the PD caregiver burden inventory (PDCB). PDQ-8 and PDCB scores were regressed on MDS-UPDRS subscales and MoCA subscores. PDQ-8 correlated with attention ( 0.1282; < 0.001) and executive ( 0.0882; 0.001) MoCA subscores and all parts of the MDS-UPDRS. PDCB correlated most strongly with MDS-UPDRS part III motor symptoms ( 0.2070; < 0.001) and the MoCA attention subscore ( 0.1815; < 0.001). While all facets of PD symptoms assessed by the MDS-UPDRS relate to PD patients' quality of life, motor symptoms are the most relevant factor for the prediction of caregiver burden. In addition, patients' attentional symptoms seem to affect not only them, but also their caregivers. These findings show the potential of a detailed analysis of MDS-UPDRS and MoCA performance in PD patients.
帕金森病（PD）是一种慢性进行性运动障碍，患者的健康相关生活质量（HR-QoL）严重下降。运动和认知症状尤其与帕金森病患者HR-QoL的降低有关。然而，这些症状与照料者负担之间的关系相对不明确。分析了蒙特利尔认知评估量表（MoCA）作为认知筛查工具以及运动障碍协会统一帕金森病评定量表MDS-UPDRS症状与患者HR-QoL和照料者负担的关系。帕金森病患者（n = 124）完成了MDS-UPDRS、MoCA以及作为生活质量衡量指标的帕金森病问卷8（PDQ-8）。照料者（n = 78）通过帕金森病照料者负担量表（PDCB）进行评估。以MDS-UPDRS分量表和MoCA子分数为自变量，对PDQ-8和PDCB分数进行回归分析。PDQ-8与MoCA注意力（r = 0.1282；P < 0.001）和执行功能（r = 0.0882；P = 0.001）子分数以及MDS-UPDRS的所有部分均相关。PDCB与MDS-UPDRS第三部分运动症状（r = 0.2070；P < 0.001）和MoCA注意力子分数（r = 0.1815；P < 0.001）的相关性最强。虽然MDS-UPDRS评估的帕金森病症状的所有方面都与帕金森病患者的生活质量相关，但运动症状是预测照料者负担的最相关因素。此外，患者的注意力症状似乎不仅影响他们自己，也影响他们的照料者。这些发现显示了详细分析帕金森病患者MDS-UPDRS和MoCA表现的潜力。
