Watanabe H, Kamikawa M, Nakagawa Y, Takahashi T, Ito A
Department of Cancer Research, Hiroshima University, Japan.
Acta Pathol Jpn. 1988 Oct;38(10):1285-96. doi: 10.1111/j.1440-1827.1988.tb02279.x.
The influence of ranitidine and cysteamine on intestinal metaplasia was examined in 7-month-old male Crj: CD (SD) rats. At the age of 5 weeks, the animals were treated with 10 Gy doses of X-rays at 3-day intervals up to a total of 20 Gy in the gastric region, and 6 months after irradiation, the rats received either ranitidine (0.02% in diet) or cysteamine (0.1% in drinking water) for 2 months. The incidence and number of intestinal metaplasia with alkaline phosphatase-positive foci in rats given X-rays and cysteamine (group 4) were significantly low compared with those in rats given X-rays and ranitidine (group 3) (p less than 0.01). In both the pyloric and the fundic gland mucosae, the average numbers of type C metaplasia (intestinal crypts with Paneth cells) and total numbers of metaplastic foci in rats of group 3 were much higher than those in group 4 (P less than 0.05). The present results showed that the occurrence of intestinal metaplasia was significantly increased after administration of ranitidine and decreased by cysteamine.
在7月龄雄性Crj:CD(SD)大鼠中研究了雷尼替丁和半胱胺对肠化生的影响。5周龄时，对动物胃部每隔3天给予10 Gy剂量的X射线，共20 Gy，照射6个月后，大鼠接受雷尼替丁（饮食中含0.02%）或半胱胺（饮用水中含0.1%）处理2个月。与接受X射线和雷尼替丁处理的大鼠（第3组）相比，接受X射线和半胱胺处理的大鼠（第4组）中碱性磷酸酶阳性灶的肠化生发生率和数量显著降低（p<0.01）。在幽门腺和胃底腺黏膜中，第3组大鼠的C型化生（含潘氏细胞的肠隐窝）平均数量和化生灶总数均显著高于第4组（P<0.05）。目前的结果表明，给予雷尼替丁后肠化生的发生率显著增加，而给予半胱胺后则降低。
