Watanabe H, Naito M, Kawashima K, Ito A
Acta Pathol Jpn. 1985 Jul;35(4):841-7. doi: 10.1111/j.1440-1827.1985.tb00626.x.
Attempts were made to examine strain differences in the susceptibility of rats to intestinal metaplasia induced by X-irradiation. The gastric regions of 4 inbred male rats (SHR, F344, WKY, and LEW strains) in 5-week-old and 2 random bred male rats (SD, and WIS strains) were irradiated with a total dose of 20 Gy X-ray given in two equal fractions separated by three days. Upon sacrifice at 6 months after the last irradiation, the number of intestinal metaplastic crypts with positive reaction to alkaline phosphatase (ALP) appeared highest in the SHR and lowest in the WIS rats. Morphologically, the number of crypts with intestinal metaplasia in whole glandular stomachs of SHR, WIS, F344, and SD rats were higher than those in WKY and LEW rats. In the pyloric gland, it was highest in WIS rats, while in the fundic gland it was highest in SHR rats. The results show that the appearance and location of intestinal metaplasia by X-irradiation are greatly influenced by the strain of the rat.
研究人员试图检测大鼠对X射线诱导的肠化生易感性的品系差异。对5周龄的4只近交系雄性大鼠（SHR、F344、WKY和LEW品系）以及2只随机繁殖的雄性大鼠（SD和WIS品系）的胃部进行照射，总剂量为20 Gy的X射线，分两次等量给予，间隔三天。在最后一次照射后6个月处死大鼠时，对碱性磷酸酶（ALP）呈阳性反应的肠化生隐窝数量在SHR大鼠中最高，在WIS大鼠中最低。形态学上，SHR、WIS、F344和SD大鼠全腺胃中出现肠化生的隐窝数量高于WKY和LEW大鼠。在幽门腺中，WIS大鼠中最高，而在胃底腺中，SHR大鼠中最高。结果表明，X射线诱导的肠化生的出现和位置受大鼠品系的影响很大。
