Hong Minli, Li Candong, Huang Baopei, Hong Chunlin, Chen Huinuan, Chen Wenxi, Liu Chaohui, Chen Huinuan Clinical Laboratory, Li Xinjian
Traditional Chinese Medicine Syndrome Research Institution, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China.
Department of Respiratory Medicine, Zhangzhou Affiliated Traditional Chinese Medicine Hospital of Fujian University of Traditional Chinese Medicine, Zhangzhou 363000, China.
J Tradit Chin Med. 2018 Aug;38(4):610-617.
To investigate the efficacy of Chaihu Ji Sang Decoction (CJSD), (a modification of Xiao Chaihu Tang (Minor Decoction of Bupleurum) was evaluated in patients with post-infection cough (PIC). Its effect on cough reflex sensitivity (CRS) was also described.
One hundred and eighteen patients with PIC were enrolled and randomly divided into an experimental group and control group (54 patients in each group). The experimental group was given CJSD orally, and the control group was given cetirizine hydrochloride for 7 d. Cough symptom scores and TCM symptom scores were compared before and after treatment. Efficacy, cough onset time, recurrence, and adverse drug reactions were additionally evaluated. Finally, CRS was evaluated before and after treatment of PIC patients in the experimental group.
Fifty-two patients in the experimental group and fifty control patients completed the study. Cough symptom scores and the TCM symptom scores of the two groups were significantly improved after treatment, however cough symptoms in the experimental group 1 (0, 2) were significantly lower than the control group 2 (1, 2) after treatment (P < 0.05). Similarly, TCM symptom scores 4 (0, 7) in the experimental group were significantly lower than the control group 6 (3, 12) (P < 0.01). Overall, the effective rate of the experimental treatment (84.60%) was significantly higher than that of the control treatment (68.00%) (P < 0.01). The onset time of efficacy of the experimental treatment was one day faster than the control treatment [2 (2,3) d vs 3 (2,3) d, P < 0.01]. The relapse rate in the experimental group (9.09%) was lower than that of the control group (29.41%) (P < 0.05). 39 PIC patients in the experimental group completed a capsaicin cough challenge test before treatment. The lgC2 and lgC5 of the experimental group prior to treatment was 1.19 (0.59, 1.49) and 1.80 (1.49, 2.10), respectively. The lgC2, lgC5 of the healthy control group was 1.49 (0.89, 2.40) and 2.70 (2.40, 3.00), respectively. The differences in lgC2 and lgC5 between experimental group and healthy groups were significant at this time point (both P < 0.01). After treatment, 34 patients in the experimental group received re-examination. lgC5 increased from 1.80 (1.49, 2.10) to 2.10 (1.49, 3.00). CRS after treatment/re-examination was significantly lower than those of baseline in the experimental group (P < 0.05).
CJSD could effectively improve the clinical symptoms of PIC patients, with demonstrable low recurrence and safety. CJSD also significantly decreased the CRS in patients with PIC.
探讨柴胡枳桑汤（由小柴胡汤化裁而来）治疗感染后咳嗽（PIC）患者的疗效，并描述其对咳嗽反射敏感性（CRS）的影响。
纳入118例PIC患者，随机分为实验组和对照组（每组54例）。实验组口服柴胡枳桑汤，对照组口服盐酸西替利嗪，疗程均为7天。比较治疗前后两组的咳嗽症状评分和中医症状评分。另外评估疗效、咳嗽起效时间、复发情况及药物不良反应。最后，对实验组PIC患者治疗前后的CRS进行评估。
实验组52例患者和对照组50例患者完成研究。两组治疗后咳嗽症状评分和中医症状评分均显著改善，但治疗后实验组咳嗽症状评分为1（0，2），显著低于对照组的2（1，2）（P<0.05）。同样，实验组中医症状评分为4（0，7），显著低于对照组的6（3，12）（P<0.01）。总体而言，实验组治疗有效率（84.60%）显著高于对照组（68.00%）（P<0.01）。实验组疗效起效时间比对照组快1天[2（2，3）天对3（2，3）天，P<0.01]。实验组复发率（9.09%）低于对照组（29.41%）（P<0.05）。实验组39例PIC患者治疗前完成了辣椒素咳嗽激发试验。实验组治疗前lgC2和lgC5分别为1.19（0.59，1.49）和1.80（1.49，2.10）。健康对照组lgC2、lgC5分别为1.49（0.89，2.40）和2.70（2.40，3.00）。此时实验组与健康组lgC2和lgC5差异有统计学意义（均P<0.01）。治疗后，实验组34例患者接受复查。lgC5从1.80（1.49，2.10）升至2.10（1.49，3.00）。实验组治疗后/复查时的CRS显著低于基线水平（P<0.05）。
柴胡枳桑汤能有效改善PIC患者的临床症状，复发率低且安全。柴胡枳桑汤还能显著降低PIC患者的CRS。
