Thumm H W, Tritschler J
Klin Monbl Augenheilkd. 1977 Jan;170(1):119-23.
A double-blind trial was performed on 12 patients with chronic open angle glaucoma with Berberin and Placebo drops. There was no evidence for the hypothesis that Berberin or Placebo cause changes in the bio-regulation of the IOP. The statistical analysis was done by a new procedure (Kannemann 1976). The authors tried to propose generally valid rules for the planning of trials which are supposed to prove or disaprove the connection between various eye-drops and IOP-changes.
对12名慢性开角型青光眼患者进行了一项使用黄连素滴眼液和安慰剂滴眼液的双盲试验。没有证据支持黄连素或安慰剂会引起眼压生物调节变化这一假设。统计分析采用了一种新方法（坎内曼，1976年）。作者试图提出一些普遍适用的试验规划规则，这些规则旨在证明或反驳各种滴眼液与眼压变化之间的联系。
