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2017 年塞拉利昂狗体内的埃博拉病毒中和抗体。

Ebola Virus Neutralizing Antibodies in Dogs from Sierra Leone, 2017.

出版信息

Emerg Infect Dis. 2020 Apr;26(4):760-763. doi: 10.3201/eid2604.190802.

DOI:10.3201/eid2604.190802
PMID:32186496
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7101121/
Abstract

Ebola virus (EBOV) is a highly pathogenic zoonotic virus for which the reservoir host has not been identified. To study the role of dogs as potential hosts, we screened 300 serum samples from dogs in Sierra Leone and found EBOV neutralizing antibodies in 12, suggesting their susceptibility to natural infection.

摘要

埃博拉病毒(EBOV)是一种高致病性人畜共患病病毒,其储存宿主尚未确定。为了研究狗作为潜在宿主的作用,我们对塞拉利昂的 300 份血清样本进行了筛查,发现其中 12 份含有埃博拉病毒中和抗体,这表明它们易受自然感染。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4f1/7101121/8458bc7d128b/19-0802-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4f1/7101121/0e37ff9aa512/19-0802-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4f1/7101121/8458bc7d128b/19-0802-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4f1/7101121/0e37ff9aa512/19-0802-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4f1/7101121/8458bc7d128b/19-0802-F2.jpg

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Antibody-Mediated Virus Neutralization Is Not a Universal Mechanism of Marburg, Ebola, or Sosuga Virus Clearance in Egyptian Rousette Bats.抗体介导的病毒中和作用不是埃及果蝠清除马尔堡病毒、埃博拉病毒或 Sosuga 病毒的普遍机制。
J Infect Dis. 2019 May 5;219(11):1716-1721. doi: 10.1093/infdis/jiy733.
3
Survey of Ebola Viruses in Frugivorous and Insectivorous Bats in Guinea, Cameroon, and the Democratic Republic of the Congo, 2015-2017.
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Emerg Infect Dis. 2018 Dec;24(12):2228-2240. doi: 10.3201/eid2412.180740. Epub 2018 Dec 17.
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