Department of Physical Education, University of Las Palmas de Gran Canaria, 35017 Las Palmas de Gran Canaria, Spain; Research Institute of Biomedical and Health Sciences (IUIBS), 35017 Las Palmas de Gran Canaria, Spain.
Research Institute of Biomedical and Health Sciences (IUIBS), 35017 Las Palmas de Gran Canaria, Spain; Department of Endocrinology and Nutrition, Hospital Universitario de Gran Canaria Doctor Negrín, 35010 Las Palmas de Gran Canaria, Spain.
Trends Endocrinol Metab. 2020 Apr;31(4):269-271. doi: 10.1016/j.tem.2020.02.003. Epub 2020 Feb 20.
Metformin has antidiabetic, anticancer, and prolongevity effects, but seems to interfere with aerobic training mitochondrial adaptations. The primary mechanism of action has been suggested to be the inhibition of mitochondrial complex I. Recent papers (Wang et al. and Cameron et al.), however, provide evidence to deny the hypothesis of a direct action of metformin on complex I.
二甲双胍具有降血糖、抗癌和延长寿命的作用，但似乎会干扰有氧训练引起的线粒体适应。其主要作用机制被认为是抑制线粒体复合物 I。然而，最近的一些论文（Wang 等人和 Cameron 等人）提供了证据，否认了二甲双胍对复合物 I 直接作用的假说。
