Cardoso Andreia-Alves, de Sousa Emerson-Tavares, Steiner-Oliveira Carolina, Parisotto Thaís-Manzano, Nobre-Dos-Santos Marinês
Department of Pediatric Dentistry, Piracicaba Dental School, University of Campinas-UNICAMP, Limeira Avenue 901, Piracicaba-SP, Brazil.
Laboratory of Microbiology and Molecular Biology, Dental School, São Francisco University, Bragança Paulista - SP, Brazil.
J Clin Exp Dent. 2020 Mar 1;12(3):e209-e214. doi: 10.4317/jced.56331. eCollection 2020 Mar.
This research aimed to evaluate the salivary concentrations of fluoride (F-), calcium (Ca2+), and phosphate (Pi) after brackets bonding, and to identify the role of [F-], [Ca2+], and [Pi] on the development of active caries lesion (ACL) in individuals under fixed orthodontic treatment.
A longitudinal investigation with twenty-two individuals from 11 to 22 years of age was performed in four phases (baseline and after 1, 3, and 6 months). Analyses were carried out considering the salivary concentration of [F-], [Ca2+], and [Pi], as well as the caries index. Data were analyzed using the Friedman test, followed by the Wilcoxon test and the multivariate Cox model (≤0.05).
1 and 3 months after appliance bonding, the [Ca2+] was statistically lower than after 6 months (<0.0083). On the other hand, salivary [F-] and [Pi] did not show any significant difference during the follow-up. The Cox model demonstrated that the increase of 1 µg/mL in Ca2+ decreased the risk of ACL development by 27%. In conclusion, the levels of Ca2+ changed during orthodontic treatment.
A high Ca2+ level in the saliva is a protective factor for ACL development over time. Adolescents, bioinorganic chemistry, dental caries, orthodontic appliances.
本研究旨在评估粘结托槽后唾液中氟离子（F-）、钙离子（Ca2+）和磷酸盐（Pi）的浓度，并确定[F-]、[Ca2+]和[Pi]在固定正畸治疗个体中活动性龋损（ACL）发展中的作用。
对22名年龄在11至22岁之间的个体进行了纵向研究，分为四个阶段（基线以及1、3和6个月后）。分析时考虑了唾液中[F-]、[Ca2+]和[Pi]的浓度以及龋病指数。数据采用Friedman检验，随后进行Wilcoxon检验和多变量Cox模型分析（≤0.05）。
矫治器粘结后1个月和3个月时，[Ca2+]在统计学上低于6个月后（<0.0083）。另一方面，在随访期间唾液中的[F-]和[Pi]没有显示出任何显著差异。Cox模型表明，Ca2+每增加1μg/mL，ACL发展的风险降低27%。总之，正畸治疗期间Ca2+水平发生了变化。
随着时间的推移，唾液中高Ca2+水平是ACL发展的一个保护因素。青少年、生物无机化学、龋齿、正畸矫治器。
