Kalani Charlene, Venigalla Tejaswi, Bailey Janay, Udeani George, Surani Salim
Medicine, Corpus Christi Medical Center, Corpus Christi, USA.
Internal Medicine, Corpus Christi Medical Center, Corpus Christi, USA.
Cureus. 2020 Feb 10;12(2):e6929. doi: 10.7759/cureus.6929.
Obesity is becoming a global health issue and its prevalence is increasing. It is associated with an increased incidence of illness and sepsis. While obesity is associated with increased morbidity and mortality, obesity has been found to be associated with improvement in mortality outcomes in sepsis when compared to leaner patients, a phenomenon described as an obesity paradox. However, the effect of obesity on mortality in adults requiring treatment for sepsis is unclear. Studies evaluating this effect are inconsistent and there is an increased morbidity still associated with obesity. As well, there are many limitations to these studies confounding interpretation. Future prospective studies minimizing bias and confounding factors are suggested to address this important clinical issue.
肥胖正成为一个全球性的健康问题，其患病率正在上升。它与疾病和脓毒症发病率的增加有关。虽然肥胖与发病率和死亡率的增加有关，但与较瘦的患者相比，肥胖已被发现与脓毒症患者死亡率结果的改善有关，这一现象被称为肥胖悖论。然而，肥胖对需要治疗脓毒症的成年人死亡率的影响尚不清楚。评估这种影响的研究结果并不一致，而且肥胖仍然与发病率增加有关。此外，这些研究存在许多局限性，混淆了对结果的解释。建议未来进行前瞻性研究，尽量减少偏倚和混杂因素，以解决这一重要的临床问题。
