Oh Tak-Kyu, Song In-Ae
Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam 13620, Republic of Korea.
Department of Anesthesiology and Pain Medicine, College of Medicine, Seoul National University, Seoul 01811, Republic of Korea.
Diagnostics (Basel). 2024 Mar 7;14(6):574. doi: 10.3390/diagnostics14060574.
Obesity is a major public health problem worldwide and is associated with increased morbidity and mortality. However, studies have shown that obesity has sepsis-related mortality benefits. We aimed to determine whether there is an improved sepsis-related survival rate in patients with obesity in South Korea. We included data from 77,810 adults with sepsis between 1 January 2013 and 31 December 2020, extracted from the National Health Insurance Service database in South Korea. The patients underwent standard health examinations within a year before sepsis, and body mass index (BMI) and waist circumference (WC) were used to reflect obesity. Lower 30-day and 1-year mortality rates were observed in the overweight and obesity groups after adjusting for confounders, including WC. However, there was no difference in mortality between the patients with severe obesity and those with normal BMI. Underweight was associated with higher 30-day and 1-year mortality. Higher 30-day and 1-year mortality was found in the high and very high WC groups. In conclusion, patients with abdominal obesity and overweight and obesity and with sepsis showed reduced mortality, whereas underweight patients with sepsis showed increased mortality in South Korea.
肥胖是全球主要的公共卫生问题，与发病率和死亡率的增加相关。然而，研究表明肥胖对脓毒症相关死亡率有有益影响。我们旨在确定韩国肥胖患者的脓毒症相关生存率是否有所提高。我们纳入了2013年1月1日至2020年12月31日期间77810例成年脓毒症患者的数据，这些数据来自韩国国民健康保险服务数据库。患者在脓毒症发生前一年内接受了标准健康检查，体重指数（BMI）和腰围（WC）用于反映肥胖情况。在调整包括WC在内的混杂因素后，超重和肥胖组的30天和1年死亡率较低。然而，重度肥胖患者和正常BMI患者的死亡率没有差异。体重过轻与30天和1年较高的死亡率相关。WC高和非常高的组中30天和1年死亡率较高。总之，在韩国，腹部肥胖、超重和肥胖且患有脓毒症的患者死亡率降低，而体重过轻且患有脓毒症的患者死亡率增加。
