Department of Dental Implantology, Hospital of Stomatology, Jilin University, Changchun 130021, China.
Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Changchun 130021, China.
Anal Cell Pathol (Amst). 2020 Mar 3;2020:1827676. doi: 10.1155/2020/1827676. eCollection 2020.
To examine the expression of RAD51 in oral squamous cell carcinoma (OSCC) and analyze its connection with pathological grade, clinical stage, and lymphatic metastasis potential.
For this study, 74 OSCC samples, 15 normal mucosa tissues, and 11 normal skin tissue samples were collected. RAD51 expression was investigated using immunohistochemistry. A follow-up visit was used to assess the prognosis of each patient. We compared RAD51 expression in oral mucosa epithelial cells (OMECs), keratinocytes, and tongue squamous cell carcinoma cells (TSCCs) by Western blot analysis.
RAD51 expression was higher in tumor cells than in normal mucosal tissues. In addition, RAD51 expression was associated with higher tumor differentiation ( < 0.05). Also, RAD51 expression was higher ( < 0.05). Also, RAD51 expression was higher ( < 0.05). Also, RAD51 expression was higher (.
A strong positive correlation was found between RAD51 expression and the degree of malignancy in OSCC patients, suggesting that RAD51 could be an excellent prognostic indicator for OSCC patients.
研究 RAD51 在口腔鳞状细胞癌（OSCC）中的表达，并分析其与病理分级、临床分期和淋巴转移潜能的关系。
本研究收集了 74 例 OSCC 样本、15 例正常口腔黏膜组织和 11 例正常皮肤组织样本。采用免疫组织化学法检测 RAD51 表达。通过随访评估每位患者的预后。通过 Western blot 分析比较口腔黏膜上皮细胞（OMECs）、角质形成细胞和舌鳞状细胞癌细胞（TSCCs）中 RAD51 的表达。
肿瘤细胞中 RAD51 的表达高于正常黏膜组织。此外，RAD51 的表达与肿瘤分化程度较高相关（<0.05）。此外，RAD51 的表达与肿瘤分期较高（<0.05）和淋巴转移潜能较高相关（<0.05）。
OSCC 患者中 RAD51 的表达与恶性程度呈强正相关，提示 RAD51 可能是 OSCC 患者的一个较好的预后指标。
