Department of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
J Immunol Res. 2020 Feb 29;2020:1704631. doi: 10.1155/2020/1704631. eCollection 2020.
Macrophages are involved in angiogenesis, an essential process for organ growth and tissue repair, and could contribute to the pathogenesis of angiogenesis-related diseases such as malignant tumors and diabetic retinopathy. Recently, long noncoding RNAs (lncRNAs) have been proved to be important in cell differentiation, organismal development, and various diseases of pathological angiogenesis. Moreover, it has been indicated that numerous lncRNAs exhibit different functions in macrophage infiltration and polarization and regulate the secretion of inflammatory cytokines released by macrophages. Therefore, the focus of macrophage-related lncRNAs could be considered to be a potential method in therapeutic targeting angiogenesis-related diseases. This review mainly summarizes the roles played by lncRNAs which associated with macrophages in angiogenesis. The possible mechanisms of the regulatory link between lncRNAs and macrophages in various angiogenesis-related diseases were also discussed.
巨噬细胞参与血管生成，这是器官生长和组织修复的必要过程，并且可能导致与血管生成相关的疾病（如恶性肿瘤和糖尿病性视网膜病变）的发病机制。最近，长链非编码 RNA（lncRNA）已被证明在细胞分化、生物体发育和病理性血管生成的各种疾病中具有重要作用。此外，已经表明许多 lncRNA 在巨噬细胞浸润和极化中表现出不同的功能，并调节巨噬细胞释放的炎症细胞因子的分泌。因此，巨噬细胞相关 lncRNA 的焦点可以被认为是治疗与血管生成相关疾病的潜在方法。本综述主要总结了与巨噬细胞相关的 lncRNA 在血管生成中的作用。还讨论了 lncRNA 与巨噬细胞在各种与血管生成相关疾病中的调控联系的可能机制。
