Department of Cardiology, The Affiliated Hospital of Qingdao University, No. 59 Haier Road, Qingdao 266100, People's Republic of China.
School of Basic Medicine, Qingdao University, No. 308 Ningxia Road, Qingdao, People's Republic of China.
Life Sci. 2023 Oct 1;330:122006. doi: 10.1016/j.lfs.2023.122006. Epub 2023 Aug 6.
Angiogenesis is a key process in organ and tissue morphogenesis, as well as growth during human development, and is coordinated by pro- and anti-angiogenic factors. When this balance is affected, the related physiological and pathological changes lead to disease. Long non-coding RNAs (lncRNAs) are an important class of non-coding RNAs that do not encode proteins, but play a dynamic role in regulating gene expression. LncRNAs have been reported to be extensively involved in angiogenesis, particularly tumor angiogenesis. The non-tumor aspects have received relatively little attention and summary, but there is a broad space for research and exploration on lncRNA-targeted angiogenesis in this area. In this review, we focus on lncRNAs in angiogenesis-related diseases other than tumors, such as atherosclerosis, myocardial infarction, stroke, diabetic complications, hypertension, osteoporosis, dermatosis, as well as, endocrine, neurological, and other systemic disorders. Moreover, multiple cell types have been implicated in lncRNA-targeted angiogenesis, but only endothelial cells have attracted widespread attention. Thus, we explore the roles of other cells. Finally, we summarize the potential research directions in the area of lncRNAs and angiogenesis that can be undertaken by combining cutting-edge technology and interdisciplinary research, which will provide new insights into the involvement of lncRNAs in angiogenesis-related diseases.
血管生成是器官和组织形态发生以及人类发育过程中生长的关键过程，由促血管生成和抗血管生成因子协调。当这种平衡受到影响时，相关的生理和病理变化会导致疾病。长链非编码 RNA（lncRNA）是一类重要的非编码 RNA，不编码蛋白质，但在调节基因表达方面发挥着动态作用。已经报道 lncRNA 广泛参与血管生成，特别是肿瘤血管生成。lncRNA 在非肿瘤方面的研究相对较少，但在这一领域，针对 lncRNA 的血管生成具有广泛的研究和探索空间。在这篇综述中，我们重点关注肿瘤以外与血管生成相关的疾病中的 lncRNA，如动脉粥样硬化、心肌梗死、中风、糖尿病并发症、高血压、骨质疏松症、皮肤病以及内分泌、神经等全身性疾病。此外，多种细胞类型被认为与 lncRNA 靶向血管生成有关，但只有内皮细胞受到广泛关注。因此，我们探讨了其他细胞的作用。最后，我们总结了通过结合前沿技术和跨学科研究可以在 lncRNA 和血管生成领域开展的潜在研究方向，这将为 lncRNA 参与血管生成相关疾病提供新的见解。
