Department of Colorectal Surgery, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing 312000, Zhejiang Province, PR China.
Key Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou 310014, Zhejiang Province, PR China; Clinical Research Institute, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou 310014, Zhejiang Province, PR China.
Life Sci. 2020 Jul 1;252:117647. doi: 10.1016/j.lfs.2020.117647. Epub 2020 Apr 8.
Approximately 98% of the human genome consists of non-coding sequences that are classified into two classes by size: small non-coding RNAs (≤200 nucleotides) and long non-coding RNAs (≥200 nucleotides). Long non-coding RNAs (lncRNAs) are involved in various cellular events and act as guides, signals, decoys, and dynamic scaffolds. Due to their oncogenic and tumor suppressive roles, lncRNAs are important in cancer development and growth. LncRNAs play their roles by modulating cancer hallmarks, including DNA damage, metastasis, immune escape, cell stemness, drug resistance, metabolic reprogramming, and angiogenesis. Angiogenesis is vital for solid tumors which guarantees their growth beyond 2 mm. Tumor angiogenesis is a complex process and is regulated through interaction between pro-angiogenic and anti-angiogenic factors within the tumor microenvironment. There are accumulating evidence that different lncRNAs regulate tumor angiogenesis. In this paper, we described the functions and mechanisms of lncRNAs in tumor angiogenesis.
人类基因组约 98%由非编码序列组成，这些序列按大小分为两类：小非编码 RNA（≤200 个核苷酸）和长非编码 RNA（≥200 个核苷酸）。长非编码 RNA（lncRNA）参与各种细胞事件，并作为向导、信号、诱饵和动态支架发挥作用。由于其致癌和肿瘤抑制作用，lncRNA 在癌症的发生和发展中具有重要作用。lncRNA 通过调节癌症标志，包括 DNA 损伤、转移、免疫逃逸、细胞干性、耐药性、代谢重编程和血管生成，发挥其作用。血管生成对于实体瘤至关重要，它保证了肿瘤生长超过 2mm。肿瘤血管生成是一个复杂的过程，通过肿瘤微环境中促血管生成和抗血管生成因子之间的相互作用来调节。越来越多的证据表明，不同的 lncRNA 调节肿瘤血管生成。本文描述了 lncRNA 在肿瘤血管生成中的功能和机制。
