Li Huimin, Du Ting, Miao Changfeng, Deng Yuan, Tian Hongwei, Fang Wei
Department of Biliary and Pancreatic Endoscopic Surgery, Gansu Provincial Hospital, Donggang West Road, Lanzhou, 730000, Gansu, China.
Department of Infections Disease, Gansu Provincial Hospital, Donggang West Road, Lanzhou, 730000, Gansu, China.
J Health Popul Nutr. 2025 Sep 2;44(1):322. doi: 10.1186/s41043-025-01062-3.
Limited research has been conducted on the effects of dietary fiber (DF) intake on gallstones. We aimed to investigate the actual DF intake in a nationally representative sample in the United States (US) and explore its association with gallstones.
We used data from the National Health and Nutrition Examination Survey database, including the 2017-2020 and 2021-2023 cycles. Using participants' gallstone histories and their average 2-day DF intake, we investigated the actual DF intake among US adults. After adjusting for traditional confounders, we used weighted multivariable logistic regression models, trend tests, spline curve fitting, subgroup analyses, and interaction tests to explore the independent association between DF intake and gallstones.
A total of 8,782 participants were included. The weighted analysis showed the prevalence of gallstones is 10.03%. The average DF intake among adult men and women is 18 ± 10 g/day and 15 ± 7.8 g/day, respectively, which is well below the recommended levels. Multivariable regression analysis revealed a statistically significant negative linear association between DF intake and gallstone prevalence. For every 10 g/day increase in DF intake, the risk of gallstones significantly decreases by 21% (OR = 0.79, 95% CI: 0.63-1.00, P = 0.047). Curve fitting showed a negative linear relationship between these two variables (P = 0.003, P for non-linearity = 0.134).
A negative linear relationship between DF intake and gallstones among adults in the US was observed, and the current DF intake in the US is far below recommended levels.
关于膳食纤维（DF）摄入量对胆结石影响的研究有限。我们旨在调查美国全国代表性样本中的实际DF摄入量，并探讨其与胆结石的关联。
我们使用了来自国家健康与营养检查调查数据库的数据，包括2017 - 2020年和2021 - 2023年周期的数据。利用参与者的胆结石病史及其平均2天的DF摄入量，我们调查了美国成年人的实际DF摄入量。在调整了传统混杂因素后，我们使用加权多变量逻辑回归模型、趋势检验、样条曲线拟合、亚组分析和交互作用检验来探讨DF摄入量与胆结石之间的独立关联。
共纳入8782名参与者。加权分析显示胆结石的患病率为10.03%。成年男性和女性的平均DF摄入量分别为18±10克/天和15±7.8克/天，远低于推荐水平。多变量回归分析显示DF摄入量与胆结石患病率之间存在统计学上显著的负线性关联。DF摄入量每增加10克/天，胆结石风险显著降低21%（OR = 0.79，95% CI：0.63 - 1.00，P = 0.047）。曲线拟合显示这两个变量之间呈负线性关系（P = 0.003，非线性P值 = 0.134）。
在美国成年人中观察到DF摄入量与胆结石之间存在负线性关系，且美国目前的DF摄入量远低于推荐水平。
