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微生物组与癌症免疫治疗。

Microbiome and cancer immunotherapy.

机构信息

Center for Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.

Department of Gynecologic Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.

出版信息

Curr Opin Biotechnol. 2020 Oct;65:114-117. doi: 10.1016/j.copbio.2020.02.007. Epub 2020 Mar 17.

DOI:10.1016/j.copbio.2020.02.007
PMID:32192986
Abstract

Immunomodulation has become a promising and growing field of cancer research. Compelling results from a variety of studies provide strong evidence for the importance of commensal bacteria on oncologic outcomes and response to antitumor immunotherapies. The gut microbiome has emerged as a new prognostic biomarker and a potential therapeutic target to enhance the efficacy of immunotherapy.

摘要

免疫调节已成为癌症研究中一个有前途且不断发展的领域。各种研究的令人信服的结果为共生细菌对肿瘤学结果和抗肿瘤免疫治疗反应的重要性提供了强有力的证据。肠道微生物组已成为一种新的预后生物标志物和潜在的治疗靶点，可增强免疫疗法的疗效。

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