State Key Laboratory of Materials Science and Technology, Yanshan University, Qinhuangdao 066004, China.
College of Chemistry and Environmental Engineering, Shanxi Datong University, Datong 037009, China.
Int J Pharm. 2020 Apr 30;580:119231. doi: 10.1016/j.ijpharm.2020.119231. Epub 2020 Mar 16.
The development of effective agents for cancer therapy and inhibition of bacterial infection has drawn a great deal of interest. Photothermal therapy has been widely used for the thermal ablation of tumor cells. In addition, antibiotics have the ability to inhibit the growth of bacteria. Thus, the combination of photothermal therapy and antibiotics may be one of the methods to address the problem. Herein, it is the first time that daptomycin (Dap) micelles were used as the template and reducing agents to prepare stable daptomycin-gold nanoflowers (Dap-AuNFs) under mild conditions. The energy dispersive spectrometer (EDS) spectrum and X-ray diffraction (XRD) spectrum indicated that Dap-AuNFs were successfully prepared. When the molar ratio of HAuCl to Dap was 6, the gold nanoparticles inside of Dap-AuNFs were about 80 nm with flower-like shape. In addition, the photothermal conversion efficiency of Dap-AuNFs was about 40%. More importantly, Dap-AuNFs inhibited the growth of tumors and bacteria under the radiation of near-infrared light at 808 nm. The prepared Dap-AuNFs could be used as photothermal antitumor and antibacterial agents in the future.
开发有效的癌症治疗药物和抑制细菌感染的药物引起了广泛关注。光热疗法已被广泛用于肿瘤细胞的热消融。此外，抗生素具有抑制细菌生长的能力。因此，光热疗法和抗生素的联合应用可能是解决这一问题的方法之一。本文首次采用达托霉素（Dap）胶束作为模板和还原剂，在温和条件下制备稳定的达托霉素-金纳米花（Dap-AuNFs）。能谱仪（EDS）谱和 X 射线衍射（XRD）谱表明成功制备了 Dap-AuNFs。当 HAuCl 与 Dap 的摩尔比为 6 时，Dap-AuNFs 内部的金纳米粒子约为 80nm，呈花状。此外，Dap-AuNFs 的光热转换效率约为 40%。更重要的是，Dap-AuNFs 在 808nm 近红外光的辐射下能抑制肿瘤和细菌的生长。制备的 Dap-AuNFs 有望在未来用作光热抗肿瘤和抗菌药物。
