Okkeh Mohammad, Bloise Nora, Restivo Elisa, De Vita Lorenzo, Pallavicini Piersandro, Visai Livia
Center for Health Technologies (CHT), Department of Molecular Medicine, INSTM UdR of Pavia, University of Pavia, Viale Taramelli 3/b, 27100 Pavia, Italy.
Medicina Clinica-Specialistica, UOR5 Laboratorio di Nanotecnologie, ICS Maugeri, IRCCS, Via S. Boezio 28, 27100 Pavia, Italy.
Nanomaterials (Basel). 2021 Jan 26;11(2):312. doi: 10.3390/nano11020312.
In 2017 the World Health Organization (WHO) announced a list of the 12 multidrug-resistant (MDR) families of bacteria that pose the greatest threat to human health, and recommended that new measures should be taken to promote the development of new therapies against these superbugs. Few antibiotics have been developed in the last two decades. Part of this slow progression can be attributed to the surge in the resistance acquired by bacteria, which is holding back pharma companies from taking the risk to invest in new antibiotic entities. With limited antibiotic options and an escalating bacterial resistance there is an urgent need to explore alternative ways of meeting this global challenge. The field of medical nanotechnology has emerged as an innovative and a powerful tool for treating some of the most complicated health conditions. Different inorganic nanomaterials including gold, silver, and others have showed potential antibacterial efficacies. Interestingly, gold nanoparticles (AuNPs) have gained specific attention, due to their biocompatibility, ease of surface functionalization, and their optical properties. In this review, we will focus on the latest research, done in the field of antibacterial gold nanoparticles; by discussing the mechanisms of action, antibacterial efficacies, and future implementations of these innovative antibacterial systems.
2017年，世界卫生组织（WHO）公布了对人类健康构成最大威胁的12个多重耐药（MDR）细菌家族名单，并建议采取新措施以促进针对这些超级细菌的新疗法的开发。在过去二十年中，几乎没有开发出新的抗生素。这种缓慢进展的部分原因可归因于细菌获得的耐药性激增，这阻碍了制药公司冒险投资新的抗生素实体。由于抗生素选择有限且细菌耐药性不断升级，迫切需要探索应对这一全球挑战的替代方法。医学纳米技术领域已成为治疗一些最复杂健康状况的创新且强大的工具。包括金、银等在内的不同无机纳米材料已显示出潜在的抗菌功效。有趣的是，金纳米颗粒（AuNPs）因其生物相容性、易于表面功能化及其光学性质而受到特别关注。在本综述中，我们将聚焦于抗菌金纳米颗粒领域的最新研究；通过讨论这些创新抗菌系统的作用机制、抗菌功效及未来应用。
