From the Department of Surgery, Division of General Surgery, University of Alberta Hospital, Edmonton, Alta. (Nostedt, Shapiro, Bigam); the Department of Physiology, University of Alberta, Edmonton, Alta. (Freed); and the Department of Surgery, Division of Cardiac Surgery, University of Alberta, Alberta Heart Institute, Edmonton, Alta. (Freed).
Can J Surg. 2020 Mar 20;63(2):E135-E141. doi: 10.1503/cjs.005519.
Reducing wait list mortality among patients awaiting liver transplantation remains a substantial challenge because of organ shortage. In efforts to expand the donor pool there has been a trend toward increased use of donation after circulatory death (DCD) liver grafts. However, these marginal grafts are prone to higher complication rates, particularly biliary complications. In addition, many procured DCD livers are then deemed unsuitable for transplant. Despite these limitations, DCD grafts represent an important resource to address the current organ shortage, and as such there are research efforts directed toward improving the use of and outcomes for transplantation of these grafts. We review the current progress in DCD liver transplantation.
由于器官短缺，降低等待肝移植患者的候补名单死亡率仍然是一个巨大的挑战。为了扩大供体库，人们越来越倾向于使用循环死亡后捐献（DCD）的肝脏移植物。然而，这些边缘供体的并发症发生率更高，特别是胆道并发症。此外，许多获取的 DCD 肝脏随后被认为不适合移植。尽管存在这些局限性，但 DCD 移植物代表了解决当前器官短缺的重要资源，因此有研究努力旨在改善这些移植物的使用和移植效果。我们回顾了 DCD 肝移植的当前进展。
