Handforth A, Ackermann R F
Department of Neurology, UCLA School of Medicine 90024.
Brain Res. 1988 Sep 13;460(1):94-102. doi: 10.1016/0006-8993(88)90433-7.
Electrical stimulation of rat amygdala induced self-sustained steady-state seizures (status epilepticus (SE] within 60 min. These SE states varied in behavioral severity from mere alteration of motility to frank clonic convulsions. Four distinct behavioral states were observed: immobility, exploration, mastication and clonus. These SE states were associated with [14C]2-deoxyglucose (2-DG) autoradiography anatomic patterns that were correspondingly more extensive and complex. Four distinct 2-DG activation patterns were observed: a restricted pattern involving several discrete limbic nuclei, including amygdala; more extensive patterns involving numerous limbic areas, first unilaterally, then bilaterally; finally the most extensive pattern involving widespread areas of forebrain. These data imply a systematic progression of seizure activity: originating in the amygdala, then spreading to some direct amygdala projection areas, and from there to a restricted network of interconnected ipsilateral limbic nuclei. This restricted network then recruits most of the remaining limbic structures, first ipsilaterally, then contralaterally. Finally, most of the basal ganglia, thalamus and neocortex are recruited.
对大鼠杏仁核进行电刺激可在60分钟内诱发持续的稳态癫痫发作（癫痫持续状态[SE]）。这些SE状态的行为严重程度各不相同，从仅仅是运动改变到明显的阵挛性惊厥。观察到四种不同的行为状态：不动、探索、咀嚼和阵挛。这些SE状态与[14C]2-脱氧葡萄糖（2-DG）放射自显影的解剖模式相关，相应地更为广泛和复杂。观察到四种不同的2-DG激活模式：一种局限模式，涉及几个离散的边缘核，包括杏仁核；更广泛的模式，涉及多个边缘区域，首先是单侧，然后是双侧；最后是最广泛的模式，涉及前脑的广泛区域。这些数据表明癫痫活动有一个系统的进展过程：起源于杏仁核，然后扩散到一些直接的杏仁核投射区域，再从那里扩散到一个有限的同侧边缘核相互连接网络。这个有限的网络随后募集大部分其余的边缘结构，首先是同侧，然后是对侧。最后，大部分基底神经节、丘脑和新皮层被募集。
