Laboratory for Translational Research in Imaging Pharmaceuticals, Department of Radiology, The Wright Center of Innovation in Biomedical Imaging, The Ohio State University, Columbus, Ohio.
Cancer Biother Radiopharm. 2020 Apr;35(3):163-166. doi: 10.1089/cbr.2019.3301. Epub 2020 Mar 20.
Gallium-68 (Ga) is an important radionuclide due to its successful use in the clinic. Currently, Ga is produced and supplied by using germanium-68/Gallium-68 (Ge/Ga) generator systems in the preclinical and clinical environments. Until recently, the supply of Ge/Ga generators, specifically the good manufacturing practices (GMP) grade, had a long lead time (up to 18 months). This led researchers to investigate the cyclotron production of Ga by using solid and liquid targets. This report summarizes an overview of the chemistry, coordination chemistry, and radiochemistry of Ga and the current status of manufacturing and supply of Ga radionuclide.
镓-68（Ga）是一种重要的放射性核素，因其在临床中的成功应用而备受关注。目前，Ga 主要通过在临床前和临床环境中使用锗-68/镓-68（Ge/Ga）发生器系统进行生产和供应。直到最近，Ge/Ga 发生器的供应，特别是良好生产规范（GMP）级别的供应，一直存在很长的交货期（长达 18 个月）。这促使研究人员开始探索使用固体和液体靶材通过回旋加速器生产 Ga。本报告总结了 Ga 的化学、配位化学和放射化学概述，以及 Ga 放射性核素的制造和供应现状。
