Agnelli G, Guerciolini R, Boldrini F, Tonzani A, Della Torre P, Nenci G G, Del Favero A
Institute of Semeiotica Medica, University of Perugia, Italy.
Chemioterapia. 1988 Dec;7(6):396-9.
The aim of this study was to compare the effects of the prophylactic use of cefamandole versus oxacillin plus gentamicin on hemostasis in patients undergoing hip replacement with heparin prophylaxis. Twenty-four patients with a normal hemostatic profile were randomly allocated to receive either cefamandole or oxacillin plus gentamicin. All the patients received calcium heparin. Platelet count, bleeding time, prothrombin time (PT), activated partial thromboplastin time (aPTT), thrombin clotting time (TCT), fibrinogen and serum FDP were assessed before treatment and every day of antibiotic administration. Surgical bleeding was assessed using a four-grade score system. Platelet count, bleeding time, fibrinogen and serum FDP did not show any change with both treatments. PT, aPTT and TCT showed a similar and mild prolongation in the two groups of patients. No difference in the surgical bleeding was observed between the two groups. We conclude that a short-term prophylaxis with cefamandole is a safe regimen in patients undergoing hip replacement with heparin prophylaxis.
本研究的目的是比较头孢孟多预防性使用与苯唑西林加庆大霉素对接受肝素预防的髋关节置换患者止血的影响。24例止血功能正常的患者被随机分配接受头孢孟多或苯唑西林加庆大霉素治疗。所有患者均接受肝素钙治疗。在治疗前以及抗生素给药的每一天，评估血小板计数、出血时间、凝血酶原时间（PT）、活化部分凝血活酶时间（aPTT）、凝血酶凝血时间（TCT）、纤维蛋白原和血清纤维蛋白降解产物（FDP）。使用四级评分系统评估手术出血量。两种治疗方法下血小板计数、出血时间、纤维蛋白原和血清FDP均未显示任何变化。两组患者的PT、aPTT和TCT均出现相似且轻微的延长。两组之间未观察到手术出血量的差异。我们得出结论，对于接受肝素预防的髋关节置换患者，短期预防性使用头孢孟多是一种安全的方案。
