Department of Pediatrics, Xinhua Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Shanghai Institute for Pediatric Research Shanghai China.
J Am Heart Assoc. 2024 Jun 18;13(12):e034165. doi: 10.1161/JAHA.123.034165. Epub 2024 Jun 14.
The association of sleep onset time and duration with cardiometabolic health is not well characterized.
This study included 6696 adults aged 20 to 80 years from the NHANES (National Health and Nutrition Examination Study) 2015 to 2018. Participants were categorized into 9 groups according to the cross-tabulation of sleep onset time (<22:00 [early], 22:00-23:59 [optimal], and ≥24:00 [late]) and duration (<7 hours [insufficient], 7-8 hours [sufficient], and ≥9 hours [excessive]), with optimal sleep onset time and sufficient duration as the reference. The primary outcomes included hypertension, hypertriglyceridemia, low high-density lipoprotein cholesterol, hyperglycemia, central obesity, and metabolic syndrome. Inappropriate sleep onset time and sleep duration were associated with increased odds of hypertension, hypertriglyceridemia, and metabolic syndrome, especially among participants aged 40 to 59 years. Compared with men reporting optimal onset and sufficient duration, men reporting optimal onset with excessive duration (odds ratio [OR]: 2.01 [95% CI, 1.12-3.58]) and late onset with insufficient duration (OR, 1.74 [95% CI, 1.13-2.68]) had higher odds of metabolic syndrome. Compared with women reporting optimal onset and sufficient duration, women reporting optimal onset and insufficient duration (OR, 1.61 [95% CI, 1.11-2.32]) and early onset and excessive duration (OR, 2.16 [95% CI, 1.30-3.57]) had higher odds of hypertension, and women reporting late onset and excessive duration (OR, 5.64 [95% CI, 1.28-6.77]) were at the highest odds of hypertriglyceridemia.
Late sleep onset as well as insufficient or excessive sleep duration are associated with adverse cardiometabolic outcomes, particularly in participants aged 40 to 59 years.
入睡时间和持续时间与心脏代谢健康的关系尚未得到充分描述。
本研究纳入了来自 NHANES（国家健康和营养检查调查）2015 年至 2018 年的 6696 名 20 至 80 岁成年人。参与者根据入睡时间（<22:00 [早], 22:00-23:59 [最佳], 和 ≥24:00 [晚])和持续时间(<7 小时 [不足], 7-8 小时 [充足], 和 ≥9 小时 [过多])的交叉分类分为 9 组，以最佳入睡时间和充足的持续时间为参考。主要结果包括高血压、高甘油三酯血症、低高密度脂蛋白胆固醇、高血糖、中心性肥胖和代谢综合征。不适当的入睡时间和睡眠时间与高血压、高甘油三酯血症和代谢综合征的发生几率增加有关，尤其是在 40 至 59 岁的参与者中。与报告最佳起始时间和充足持续时间的男性相比，报告最佳起始时间和过多持续时间的男性（比值比 [OR]：2.01 [95%置信区间，1.12-3.58]）和晚起始时间和不足持续时间的男性（OR，1.74 [95%置信区间，1.13-2.68]）发生代谢综合征的几率更高。与报告最佳起始时间和充足持续时间的女性相比，报告最佳起始时间和不足持续时间的女性（比值比 [OR]：1.61 [95%置信区间，1.11-2.32]）和早起始时间和过多持续时间的女性（OR，2.16 [95%置信区间，1.30-3.57]）发生高血压的几率更高，而报告晚起始时间和过多持续时间的女性（OR，5.64 [95%置信区间，1.28-6.77]）发生高甘油三酯血症的几率最高。
入睡时间晚以及睡眠时间不足或过多与不良的心脏代谢结局有关，尤其是在 40 至 59 岁的参与者中。
