School of Biology and Food Engineering, Hefei University of Technology, Hefei, 230009, China.
J Sci Food Agric. 2013 Jun;93(8):1833-8. doi: 10.1002/jsfa.5974. Epub 2012 Dec 12.
The ability of sesamin from sesame meal to ameliorate insulin resistance in KK-Ay mice (an animal model of type 2 diabetes) was evaluated.
Treatment with sesamin (100 or 50 mg kg(-1)) significantly decreased the level of fasting plasma glucose, glycosylated serum protein, serum insulin, triglycerides, cholesterol, free fatty acid and malondialdehyde content of livers. Treatment with sesamin significantly increased the content of hepatic glycogen, reduced glutathione and the activity of superoxide dismutase and glutathione peroxidase. Moreover, the insulin-binding capacity to liver crude plasma membranes increased and histopathological changes of the pancreas were ameliorated in the treatment group.
Sesamin has hypoglycaemic, hypolipidaemic and the ability to ameliorate insulin resistance in KK-Ay mice, which might be related to its effect on insulin receptors, and thus increases insulin sensitivity.
评价芝麻素（来自芝麻饼粕的一种物质）改善 KK-Ay 小鼠（2 型糖尿病动物模型）胰岛素抵抗的能力。
芝麻素（100 或 50mg/kg）治疗可显著降低禁食血浆葡萄糖、糖化血清蛋白、血清胰岛素、甘油三酯、胆固醇、游离脂肪酸和肝脏丙二醛含量。芝麻素治疗可显著增加肝糖原、还原型谷胱甘肽含量，提高超氧化物歧化酶和谷胱甘肽过氧化物酶活性。此外，胰岛素与肝粗质膜的结合能力增加，胰腺的组织病理学变化得到改善。
芝麻素具有降血糖、降血脂和改善 KK-Ay 小鼠胰岛素抵抗的作用，这可能与其对胰岛素受体的作用有关，从而提高了胰岛素敏感性。
