Department of Ophthalmology, Bursa Yuksek Ihtisas Training and Research Hospital, Mimar Sinan Mah. Emniyet Cad. Polis Okulu Karşısı Yıldırım, 16310, Bursa, Turkey.
Int Ophthalmol. 2020 Jul;40(7):1765-1772. doi: 10.1007/s10792-020-01345-0. Epub 2020 Mar 21.
The aim of this study was to compare the macular and peripapillary capillary vessel density (CVD) and foveal avascular zone (FAZ) in amblyopic eyes of adults with their fellow eyes and with eyes of healthy controls using optical coherence tomography-angiography (OCT-A).
A total of 34 eyes of 17 patients with anisometropic amblyopia and 80 eyes of 40 age- and gender-matched healthy controls were included. CVD in superficial (SCP) and deep retinal capillary plexuses (DCP), peripapillary region, and FAZ were analyzed by OCT-A.
The median ages were 31 years (range 20-64) in patients with amblyopia and 34.5 years (range 24-65) in healthy controls (p = 0.242). The mean FAZ area measured was 0.329 ± 0.024 mm in amblyopic eyes, 0.332 ± 0.025 mm in fellow eyes, and 0.269 ± 0.015 mm in control eyes (p < 0.05). The amblyopic eye of participants showed a decrease in CVD of SCP and DCP (p < 0.001, for all). The inside optic disk CVD measurements were lower in the amblyopic eyes than in the fellow eyes (p = 0.001) and healthy subjects (p = 0.015).
Significant differences in macular and peripapillary microvasculature were found in anisometropic amblyopic patients. The clinical significance of the results requires further investigation.
本研究旨在通过光学相干断层扫描血管造影术（OCT-A）比较成人弱视眼与其对侧眼和健康对照眼的黄斑和视盘周围毛细血管密度（CVD）和中心凹无血管区（FAZ）。
共纳入 34 只患有屈光参差性弱视眼的 17 名患者和 80 只年龄和性别匹配的健康对照眼的 40 名患者。通过 OCT-A 分析浅层视网膜毛细血管丛（SCP）和深层视网膜毛细血管丛（DCP）、视盘周围区域和 FAZ 的 CVD。
弱视患者的中位年龄为 31 岁（范围 20-64 岁），健康对照者的中位年龄为 34.5 岁（范围 24-65 岁）（p=0.242）。弱视眼的平均 FAZ 面积为 0.329±0.024mm，对侧眼为 0.332±0.025mm，对照组为 0.269±0.015mm（p<0.05）。参与者的弱视眼 SCP 和 DCP 的 CVD 降低（p<0.001，均）。弱视眼的视盘内 CVD 测量值低于对侧眼（p=0.001）和健康受试者（p=0.015）。
在屈光参差性弱视患者中发现了黄斑和视盘周围微血管的显著差异。结果的临床意义需要进一步研究。
