Peng Chuanming, Lu Yanqin, Ren Xiuzhi, Wang Yanzhou, Zhang Shie, Chen Mei, Liu Junlong, Fang Fengling, Li Tianyou, Han Jinxiang
School of Medicine and Life Sciences, University of Jinan, Shandong Academy of Medical Sciences, Ji'nan, China.
Key Laboratory for Biotech Drugs of the National Health Commission, Key Laboratory for Rare & Uncommon Diseases of Shandong Province, Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, China.
Intractable Rare Dis Res. 2020 Feb;9(1):14-22. doi: 10.5582/irdr.2020.01018.
Wnt1 is the first member of the Wnt family that was identified. It is phylogenetically conserved and essential for oncogenesis and multiple developmental processes. This study has summarized diseases and mutations related to . is involved in various cancers, genetic type XV osteogenesis imperfecta, osteoporosis, and neurological diseases. The expression of in normal tissues and different types of cancers and the potential survival of cancer were analyzed using experiment-based bioinformatic analysis. Systematic analysis indicated that abnormal expression of is significantly associated with cancers, such as kidney renal carcinoma, hepatocellular carcinoma, thyroid carcinoma, head and neck squamous cell carcinoma, and uterine corpus endometrial carcinoma. GeneMANIA and STRING predicted that 32 proteins were involved with Wnt1 in Wnt signaling pathways and sorting and secretion of Wnts. These interacting molecules significantly co-occurred according to cBioPortal analysis. Thirty-three genes with an alteration frequency of more than 50% were observed in several cancers like esophageal squamous cell carcinoma, melanoma, and non-small cell lung cancer. Functional and experiment-based bioinformatics indicated that Wnt1 may act as a target of a potential biomarker for various types of human cancers. Wnt1 and other Wnt1-related proteins and signaling pathways may be ways to treat osteoporosis.
Wnt1是Wnt家族中第一个被鉴定出来的成员。它在系统发育上具有保守性，对肿瘤发生和多个发育过程至关重要。本研究总结了与之相关的疾病和突变。它涉及多种癌症、XV型遗传性骨生成不全、骨质疏松症和神经系统疾病。利用基于实验的生物信息学分析，分析了其在正常组织和不同类型癌症中的表达以及癌症患者的潜在生存率。系统分析表明，其异常表达与肾癌、肝癌、甲状腺癌、头颈部鳞状细胞癌和子宫内膜癌等癌症显著相关。GeneMANIA和STRING预测，32种蛋白质参与Wnt信号通路中Wnt1的作用以及Wnts的分选和分泌。根据cBioPortal分析，这些相互作用分子显著共现。在食管癌、黑色素瘤和非小细胞肺癌等几种癌症中观察到33个改变频率超过50%的基因。基于功能和实验的生物信息学表明，Wnt1可能作为多种人类癌症潜在生物标志物的靶点。Wnt1及其他与Wnt1相关的蛋白质和信号通路可能是治疗骨质疏松症的途径。
