Gregersen H, Jensen L S, Djurhuus J C
Institute of Experimental Clinical Research, University of Aarhus, Denmark.
Gut. 1988 Dec;29(12):1699-704. doi: 10.1136/gut.29.12.1699.
The biomechanical properties of the oesophageal wall were investigated in a rabbit model using a four electrode impedance technique. A specially designed probe with the electrodes inside a low pressure expandable insulating latex balloon was introduced in the oesophagus. Stepwise inflation and deflation was done for analysis of oesophageal compliance and hysteresis. The rabbits were allocated to three groups: a control group, one with oesophageal varices and one with varices which were treated by sclerotherapy. The oesophageal varices were induced by portal banding five months before the investigation. A uniform pattern of changes in the biomechanical properties of the oesophageal wall was seen in the group with oesophageal varices when compared with controls. The compliance was significantly decreased, and the hysteresis was lessened. Endoscopic sclerotherapy changed the wall properties to a pattern not distinguishable from normal. Thus, in vivo investigation of the biomechanical wall properties showed a significant loss of distensibility of the oesophagus with varices and restorement of the wall distensibility when the varices were treated with endoscopic sclerotherapy.
采用四电极阻抗技术在兔模型中研究食管壁的生物力学特性。将一个特殊设计的探头插入食管，探头的电极位于低压可扩张的绝缘乳胶球囊内。通过逐步充气和放气来分析食管顺应性和滞后现象。将兔子分为三组：对照组、一组患有食管静脉曲张组和一组接受硬化治疗的静脉曲张组。在研究前五个月通过门静脉结扎诱导食管静脉曲张。与对照组相比，食管静脉曲张组食管壁生物力学特性呈现出一致的变化模式。顺应性显著降低，滞后现象减轻。内镜下硬化治疗使食管壁特性改变为与正常无法区分的模式。因此，对食管壁生物力学特性的体内研究表明，患有静脉曲张的食管扩张性显著丧失，而当静脉曲张接受内镜下硬化治疗时，食管壁扩张性得以恢复。
