Baxter A J, Mangnall Y F, Loj E H, Brown B, Barber D C, Johnson A G, Read N W
Sub-Department of Human Gastrointestinal Physiology, University of Sheffield.
Gut. 1988 Dec;29(12):1730-5. doi: 10.1136/gut.29.12.1730.
Applied potential tomography (APT) is a new, non-invasive technique that can yield sequential images of changes in the resistivity of gastric contents. Studies were performed to investigate the application of APT to measure gastric acid secretion. Experiments in 20 normal volunteers showed that changes in gastric resistivity were closely correlated with changes in the volume (r = 0.80), the acidity (r = 0.83) and the total conductivity of gastric contents (r = 0.87). Studies in 13 patients referred for a pentagastrin test showed that changes in gastric resistivity before pentagastrin were closely correlated with basal acid output measured on a separate occasion (r = 0.85, p less than 0.001), while changes in gastric resistivity after pentagastrin were correlated with maximal acid output (r = 0.58, p less than 0.05). Ingestion of alcohol by six normal subjects decreased gastric resistivity markedly, probably due to alcohol induced gastric acid secretion as it was prevented by cimetidine. Applied potential tomography is a safe non-invasive method of measuring gastric acid secretion. The equipment is simple to use, and the test is comfortable and acceptable to patients.
应用电位断层扫描（APT）是一种新型的非侵入性技术，能够生成胃内容物电阻率变化的序列图像。开展了多项研究以探讨APT在测量胃酸分泌方面的应用。对20名正常志愿者进行的实验表明，胃电阻率的变化与胃内容物的体积变化（r = 0.80）、酸度变化（r = 0.83）以及总电导率变化（r = 0.87）密切相关。对13名接受五肽胃泌素试验的患者进行的研究表明，五肽胃泌素给药前胃电阻率的变化与在另一个时间点测得的基础胃酸分泌量密切相关（r = 0.85，p < 0.001），而五肽胃泌素给药后胃电阻率的变化与最大胃酸分泌量相关（r = 0.58，p < 0.05）。6名正常受试者摄入酒精后胃电阻率显著降低，这可能是由于酒精诱导胃酸分泌所致，因为西咪替丁可防止这种情况发生。应用电位断层扫描是一种测量胃酸分泌的安全非侵入性方法。该设备使用简便，且该测试对患者来说舒适且可接受。
