Yang Linxin, He Jinshen, Liu Jiahao, Xie Tianjian, Tang Qi
Department of Rheumatology and Immunology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Clinical Medical Research Center for Systemic Autoimmune Diseases in Hunan Province, Changsha, Hunan, China.
Department of Orthopaedic Surgery, the Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Curr Res Transl Med. 2024 Sep;72(3):103442. doi: 10.1016/j.retram.2024.103442. Epub 2024 Feb 6.
Chimeric antigen receptor therapy beyond oncology has gained increasing attention. While a substantial number of publications have emerged in recent years, there has been a paucity of conducted bibliometric studies. Our objective is to systematically summarize and visually analyze the literature in the field of chimeric antigen receptors therapy beyond oncology and explore hotspots in this field.
Web of Science Core Collection was selected as the data source, and the data was retrieved on December 23, 2022, according to the search strategy. CiteSpace 6.1.R6 and Vosviewer 1.6.18 were used to analyze publications and explore research hotspots and directions.
A total of 338 publications written by 1832 authors from 516 institutions in 42 countries/regions were selected for the analysis. The number of publications is steadily increasing annually. The United States emerged as the primary contributor, and University of Pennsylvania was the leading institution. Frontiers in Immunology boasted the highest number of published papers. Kitchen SG, Riley JL, and Scott DW were the most productive researchers in this field. The keyword cluster analysis identified HIV, autoimmune diseases, transplant related diseases and COVID-19 as the primary focus areas within the realm of chimeric antigen receptor therapy beyond oncology.
The advancement of chimeric antigen receptor therapy beyond oncology has witnessed rapid progress in recent years. We have explored the hotspots and research directions in this field. It is hoped that this study could provide references and directions for future clinical researches.
嵌合抗原受体疗法在肿瘤学以外领域的应用日益受到关注。尽管近年来出现了大量相关出版物，但进行文献计量学研究的却很少。我们的目的是系统地总结和直观分析肿瘤学以外嵌合抗原受体疗法领域的文献，并探索该领域的热点。
选择Web of Science核心合集作为数据源，根据检索策略于2022年12月23日进行数据检索。使用CiteSpace 6.1.R6和Vosviewer 1.6.18分析出版物，探索研究热点和方向。
共筛选出来自42个国家/地区516个机构的1832名作者撰写的338篇出版物进行分析。出版物数量逐年稳步增加。美国是主要贡献者，宾夕法尼亚大学是领先机构。《免疫学前沿》发表的论文数量最多。Kitchen SG、Riley JL和Scott DW是该领域产出最多的研究人员。关键词聚类分析确定，在肿瘤学以外的嵌合抗原受体疗法领域，HIV、自身免疫性疾病、移植相关疾病和COVID-19是主要关注领域。
近年来，肿瘤学以外的嵌合抗原受体疗法取得了快速进展。我们探索了该领域的热点和研究方向。希望本研究能为未来的临床研究提供参考和方向。
