Zeng Di, Zeng Qingyue, Wang Shaofeng, Li Shuangqing
Division of Biliary Tract Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
General Practice Ward/International Medical Center Ward, General Practice Medical Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Diabetol Metab Syndr. 2024 Aug 30;16(1):212. doi: 10.1186/s13098-024-01437-2.
Diabetes mellitus (DM) and Helicobacter pylori infection (HPI) pose increasing public health challenges in aging societies, sharing common pathophysiological mechanisms, and linked to significant health risks. Our study examines their respective impacts on all-cause and cardiovascular mortalities in a comprehensive longitudinal population-based analysis.
The study analyzed data from the National Health and Nutrition Examination Survey (NHANES) database conducted between 1999 and 2019, which included information on Diabetes mellitus status and Helicobacter pylori infection status. Mortality data were obtained from the same database mentioned above.
Among the 2719 participants, 1362 (50.1%) were free of both diabetes mellitus (DM) and Helicobacter pylori infection (HP) (DM -/HP -), 140 (5.1%) had DM alone (DM +/HP -), 1011 (37.2%) had HP alone (DM -/HP +), and 206 (7.6%) had both DM and HP (DM +/HP +). Compared to the DM -/HP - group, the DM +/HP - and DM + /HP + groups demonstrated increased all-cause mortality with adjusted hazard ratios (HRs) of 1.40 (95% [CI] 1.07-1.78) and 1.46 (95% CI 1.15-1.84), respectively. For diabetic mortality, DM +/HP- group and DM + /HP + group showed increased HR of 6.30 (95% CI 1.30-30.43) and 8.56 (95% CI 1.98-36.94), respectively. For cardiovascular mortality, the DM + /HP- group and DM + /HP + group exhibited increased HR of 1.75 (95% CI 1.14-2.69) and 1.98 (95% CI 1.40-2.79), respectively. The DM + /HP + cohort displayed the highest risk of overall mortality (p for trend = 0.003), diabetic mortality (p for trend < 0.0001), an6d cardiovascular mortality (p for trend < 0.0001).
The concurrent presence of DM and Helicobacter pylori infection significantly amplifies the risk of all-cause, cardiovascular, and diabetic mortality. Individuals with either condition may necessitate heightened management to prevent the onset of the other ailment and reduce mortality rates.
在老龄化社会中，糖尿病（DM）和幽门螺杆菌感染（HPI）对公共卫生构成了日益严峻的挑战，它们具有共同的病理生理机制，并与重大健康风险相关。我们的研究在一项基于人群的综合纵向分析中，考察了它们对全因死亡率和心血管死亡率的各自影响。
该研究分析了1999年至2019年期间进行的美国国家健康与营养检查调查（NHANES）数据库中的数据，其中包括糖尿病状态和幽门螺杆菌感染状态的信息。死亡率数据来自上述同一数据库。
在2719名参与者中，1362名（50.1%）既无糖尿病（DM）也无幽门螺杆菌感染（HP）（DM-/HP-），140名（5.1%）仅有糖尿病（DM+/HP-），1011名（37.2%）仅有幽门螺杆菌感染（DM-/HP+），206名（7.6%）既有糖尿病又有幽门螺杆菌感染（DM+/HP+）。与DM-/HP-组相比，DM+/HP-组和DM+/HP+组的全因死亡率增加，调整后的风险比（HRs）分别为1.40（95%[CI]1.07 - 1.78）和1.46（95%CI 1.15 - 1.84）。对于糖尿病死亡率，DM+/HP-组和DM+/HP+组的HR分别增加了6.30（95%CI 1.30 - 30.43）和8.56（95%CI 1.98 - 36.94）。对于心血管死亡率，DM+/HP-组和DM+/HP+组的HR分别增加了1.75（95%CI 1.14 - 2.69）和1.98（95%CI 1.40 - 2.79）。DM+/HP+队列显示出总体死亡率（趋势p = 0.003）、糖尿病死亡率（趋势p < 0.0001）和心血管死亡率（趋势p < 0.0001）的最高风险。
糖尿病和幽门螺杆菌感染同时存在显著增加了全因、心血管和糖尿病死亡的风险。患有这两种疾病之一的个体可能需要加强管理，以预防另一种疾病的发生并降低死亡率。
