Zhang W, Li X M, Xu D, Liu D Z, Xu J, Zhao F T, Zhao Y, Zeng X F, Dong Y
Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing 100730, China.
Department of Rheumatology, Anhui Provincial Hospital, He Fei 230036, China.
Zhonghua Nei Ke Za Zhi. 2020 Apr 1;59(4):269-276. doi: 10.3760/cma.j.cn112138-20200113-00021.
Sjögren's syndrome is a chronic systemic autoimmune disease characterized by lymphocyte proliferation and progressive exocrine gland damage. In China, standardized diagnosis and treatment for Sjögren's syndrome lags behind other common rheumatic diseases, such as rheumatoid arthritis and systemic lupus erythematosus. Based on the evidence and guidelines from China and other countries, Chinese Sjögren's Syndrome Collaborative Research Group together with stomatologist and ophthalmologist developed Standardization of diagnosis and treatment of primary Sjögren's syndrome. The purposes are: (1) to standardize the detection and interpretation of key indicators for the diagnosis of Sjögren's syndrome, including serum anti SSA antibody and labial gland pathology; (2) to suggest using widely accepted disease activity index in evaluation of the disease; (3) to standardize rational management for Sjögren's syndrome patients with topical and systemic diseases.
干燥综合征是一种慢性全身性自身免疫性疾病，其特征为淋巴细胞增殖和进行性外分泌腺损伤。在中国，干燥综合征的标准化诊断和治疗落后于其他常见的风湿性疾病，如类风湿关节炎和系统性红斑狼疮。基于中国和其他国家的证据及指南，中国干燥综合征协作研究组联合口腔医学专家和眼科专家制定了原发性干燥综合征的诊断和治疗规范。目的如下：（1）规范干燥综合征诊断关键指标的检测及解读，包括血清抗SSA抗体和唇腺病理；（2）建议在疾病评估中使用广泛认可的疾病活动指数；（3）规范干燥综合征合并局部和全身性疾病患者的合理管理。
