Chen Xiao-Yan, Chen Zhi-Ye, Dong Zhao, Liu Meng-Qi, Yu Sheng-Yuan
Department of Neurology, First Medical Center of Chinese PLA General Hospital, Beijing, China.
Department of Radiology, First Medical Center of Chinese PLA General Hospital, Beijing; Department of Radiology, Hainan Hospital of First Medical Center of Chinese PLA General Hospital, Sanya, Hainan Province, China.
Neural Regen Res. 2020 Sep;15(9):1701-1708. doi: 10.4103/1673-5374.276360.
The pathophysiology of migraine is complex. Neuroimaging studies reveal functional and structural changes in the brains of migraine patients. We sought to explore regional volume differences in intracranial structures in patients with episodic and chronic migraine. Sixteen episodic migraine patients, 16 chronic migraine patients, and 24 normal controls were recruited and underwent 3.0 T MRI scanning. The volumes of 142 brain regions were calculated by an automatic volumetric algorithm and compared with clinical variables. Results demonstrated that the volumes of specific regions in the frontal and occipital lobes, and the right putamen, were increased and the volume of the fourth ventricle was decreased in the episodic migraine patients compared with controls. The volumes of the left basal forebrain, optic chiasm, and, the fourth ventricle were decreased in the chronic migraine patients, while the occipital cortex and the right putamen were larger. Compared to episodic migraine patiants, chronic migraine patients displayed larger left thalamus and smaller frontal regions. Correlation analysis showed that headache frequency was negatively correlated with the volume of the right frontal pole, right lateral orbital gyrus, and medial frontal lobes and positively correlated with the volume of the left thalamus. The sleep disturbance score was negatively correlated with the volume of the left basal forebrain. This suggests that migraine patients have structural changes in regions associated with pain processing and modulation, affective and cognitive processing, and visual perception. The remodeling of selective intracranial structures may be involved in migraine attacks. This study was approved by the Ethics Committee of Chinese PLA General Hospital (approval No. S2018-027-02) on May 31, 2018.
偏头痛的病理生理学很复杂。神经影像学研究揭示了偏头痛患者大脑中的功能和结构变化。我们试图探究发作性和慢性偏头痛患者颅内结构的区域体积差异。招募了16名发作性偏头痛患者、16名慢性偏头痛患者和24名正常对照者，并对其进行了3.0T磁共振成像扫描。通过自动容积算法计算了142个脑区的体积，并与临床变量进行了比较。结果表明，与对照组相比，发作性偏头痛患者额叶和枕叶的特定区域以及右侧壳核的体积增加，第四脑室的体积减小。慢性偏头痛患者左侧基底前脑、视交叉和第四脑室的体积减小，而枕叶皮质和右侧壳核较大。与发作性偏头痛患者相比，慢性偏头痛患者左侧丘脑较大，额叶区域较小。相关性分析表明，头痛频率与右侧额极、右侧眶外侧回和额内侧叶的体积呈负相关，与左侧丘脑的体积呈正相关。睡眠障碍评分与左侧基底前脑的体积呈负相关。这表明偏头痛患者在与疼痛处理和调节、情感和认知处理以及视觉感知相关的区域存在结构变化。选择性颅内结构的重塑可能参与了偏头痛发作。本研究于2018年5月31日获得中国人民解放军总医院伦理委员会批准（批准号：S2018-027-02）。
