玻璃体内注射干细胞治疗Usher综合征后出现慢性视网膜脱离和新生血管性青光眼。

Khine Kay T, Albini Thomas A, Lee Richard K

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.

Am J Ophthalmol Case Rep. 2020 Mar 7;18:100647. doi: 10.1016/j.ajoc.2020.100647. eCollection 2020 Jun.

A 42-year-old Hispanic female underwent intravitreal autologous adipose-tissue derived stem cell injection to her left eye in the Dominican Republic for treatment of retinitis pigmentosa associated with Usher Syndrome. Prior to intravitreal injection, the patient's best-corrected-visual-acuity (BCVA) was 1/200. The patient experienced decreased vision gradually over a 3-month period. The patient presented with no light perception (NLP) vision with a total funnel retinal detachment, as well as hyphema, iris neovascularization, and nearly 360 posterior synechiae of the iris to the lens capsule. The patient suffered from ocular pain with an intraocular pressure (IOP) of 37 mm Hg. Transcleral cyclophotocoagulation was performed. The IOP was 6 mm Hg six weeks after treatment and the patient was pain free.

一名42岁的西班牙裔女性在多米尼加共和国接受了左眼玻璃体内自体脂肪组织来源干细胞注射，用于治疗与Usher综合征相关的色素性视网膜炎。在玻璃体内注射前，患者的最佳矫正视力（BCVA）为1/200。患者在3个月内视力逐渐下降。患者就诊时无光感（NLP），伴有完全性漏斗状视网膜脱离，以及前房积血、虹膜新生血管形成，虹膜与晶状体囊膜几乎360°后粘连。患者眼压为37 mmHg，伴有眼痛。遂进行了经巩膜睫状体光凝术。治疗六周后眼压为6 mmHg，患者无痛。