Carbon-11 carboxylation of trialkoxysilane and trimethylsilane derivatives using [C]CO.

A novel carboxylation radiosynthesis methodology is described starting from cyclotron-produced [C]CO and fluoride-activated silane derivatives. Six carbon-11 labelled carboxylic acids were obtained from their corresponding trimethylsilyl and trialkoxysilyl precursors in a one-pot labelling methodology. The radiochemical yields ranged from 19% to 93% within 12 minutes post [C]CO delivery with a trapping efficiency of 21-89%.