School of Biomedical Engineering & Imaging Sciences, King's College London, King's Health Partners, St Thomas' Hospital, London SE1 7EH, UK.
Chem Commun (Camb). 2020 Apr 30;56(34):4668-4671. doi: 10.1039/d0cc00449a. Epub 2020 Mar 25.
A novel carboxylation radiosynthesis methodology is described starting from cyclotron-produced [C]CO and fluoride-activated silane derivatives. Six carbon-11 labelled carboxylic acids were obtained from their corresponding trimethylsilyl and trialkoxysilyl precursors in a one-pot labelling methodology. The radiochemical yields ranged from 19% to 93% within 12 minutes post [C]CO delivery with a trapping efficiency of 21-89%.
描述了一种新颖的羧化放射合成方法，从回旋加速器产生的[C]CO 和氟化物激活的硅烷衍生物开始。六种碳-11 标记的羧酸通过其相应的三甲基硅基和三烷氧基硅基前体在一锅标记方法中获得。在[C]CO 输送后 12 分钟内，放射性化学产率范围为 19%至 93%，捕获效率为 21%至 89%。
