Yamaguchi T, Hayashi K, Murakami H, Ota K, Maruyama S
Neurochem Res. 1982 May;7(5):627-36. doi: 10.1007/BF00965128.
Glutamate dehydrogenase (GDH) activity in leukocytes and platelets in spinocerebellar degenerations (SCD) was determined. In the same subject, GDH activity was higher and more reproducible in platelets than in leukocytes. GDH was decreased significantly in olivopontocerebellar atrophy (OPCA) (Ca. 30% decrease). Pyruvate dehydrogenase (PDH) in platelets showed non specific decreased activity in SCD and amyotropic lateral sclerosis. Energy metabolism in cerebellum may be diminished in some types of ataxia, and glutaminergic neurons may be more affected in OPCA than in other SCD.
测定了脊髓小脑变性（SCD）患者白细胞和血小板中的谷氨酸脱氢酶（GDH）活性。在同一受试者中，血小板中的GDH活性高于白细胞，且更具重复性。橄榄桥脑小脑萎缩（OPCA）患者的GDH活性显著降低（约降低30%）。血小板中的丙酮酸脱氢酶（PDH）在SCD和肌萎缩侧索硬化症中表现出非特异性的活性降低。在某些类型的共济失调中，小脑的能量代谢可能会减弱，并且OPCA中的谷氨酰胺能神经元可能比其他SCD更易受影响。
