Department of Anesthesiology, Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
Department of Anesthesiology, The Second Affiliated Hospital of Jiaxing University, Jiaxing City, Zhejiang Province, China.
Mediators Inflamm. 2020 Mar 7;2020:3736912. doi: 10.1155/2020/3736912. eCollection 2020.
Postoperative cognitive dysfunction increases mortality and morbidity in perioperative patients. Numerous studies have demonstrated that multiple surgery/anesthesia during the neurodevelopmental period affects cognitive function, whereas a single anesthesia/surgery rarely causes cognitive dysfunction in adults. However, whether adults who undergo multiple anesthesia/surgery over a short period will experience cognitive dysfunction remains unclear. In this study, central nervous system inflammation and changes in cholinergic markers were investigated in adult mice subjected to multiple laparotomy procedures over a short period of time. The results showed that despite the increased expression of IL-6 and TNF- in the hippocampus after multiple operations and the activation of microglia, multiple anesthesia/surgery did not cause a decline in cognitive function in adult mice. There were no changes in the cholinergic markers after multiple anesthesia/surgery.
术后认知功能障碍会增加围手术期患者的死亡率和发病率。大量研究表明，神经发育期间多次手术/麻醉会影响认知功能，而单次麻醉/手术很少会导致成年人出现认知功能障碍。然而，在短时间内多次接受麻醉/手术的成年人是否会出现认知功能障碍尚不清楚。在这项研究中，研究人员研究了在短时间内多次接受剖腹手术的成年小鼠的中枢神经系统炎症和胆碱能标志物的变化。结果表明，尽管多次手术后海马体中的 IL-6 和 TNF-α表达增加，小胶质细胞被激活，但多次麻醉/手术并未导致成年小鼠认知功能下降。多次麻醉/手术后胆碱能标志物没有变化。
