• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

艾灸对高蛋氨酸饮食诱导的高同型半胱氨酸血症和氧化应激的影响。

Effect of Moxibustion on Hyperhomocysteinemia and Oxidative Stress Induced by High-Methionine Diet.

作者信息

Wang Hao, Ha Lue, Hui Xin, Lin Yao, He Rui, Baixiao Zhao

机构信息

Beijing University of Chinese Medicine, Beijing, China.

出版信息

Evid Based Complement Alternat Med. 2020 Mar 9;2020:3184785. doi: 10.1155/2020/3184785. eCollection 2020.

DOI:10.1155/2020/3184785
PMID:32215035
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7085384/
Abstract

OBJECTIVE

The aim of this study was to assess the effects of moxibustion on the animal model of oxidative stress and cardiovascular injury induced by high-methionine diet (2% methionine and 3.5% fat on the basis of ordinary maintenance feed) during 12 weeks.

METHODS

53 mice were divided into four groups: mice in the Control group ( = 8), mice in the Met group ( = 8), mice in the Met group ( = 8), mice in the Met group ( = 8), mice in the Met group (.

RESULTS

Compared with the Met group, our results indicated that through moxibustion intervention, the content of serum Hcy and its intermediate metabolite SAH can be reduced to a certain extent, and SOD, HO-1, and ox-LDL can be increased.

CONCLUSION

This study showed moxibustion's ability to enhance the body's antioxidation and protect vascular endothelial function, thus playing an early role in the prevention and treatment of atherosclerosis.

摘要

目的

本研究旨在评估艾灸对高蛋氨酸饮食（在普通维持饲料基础上含2%蛋氨酸和3.5%脂肪）诱导的氧化应激和心血管损伤动物模型在12周期间的影响。

方法

53只小鼠分为四组：对照组小鼠（n = 8），蛋氨酸组小鼠（n = 8），蛋氨酸组小鼠（n = 8），蛋氨酸组小鼠（n = 8），蛋氨酸组小鼠（.

结果

与蛋氨酸组相比，我们的结果表明，通过艾灸干预，血清同型半胱氨酸及其中间代谢产物S-腺苷同型半胱氨酸的含量可在一定程度上降低，超氧化物歧化酶、血红素加氧酶-1和氧化型低密度脂蛋白可增加。

结论

本研究表明艾灸具有增强机体抗氧化作用和保护血管内皮功能的能力，从而在动脉粥样硬化的防治中发挥早期作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c74/7085384/8fa670a508ef/ECAM2020-3184785.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c74/7085384/4d05d9866763/ECAM2020-3184785.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c74/7085384/30246fac6907/ECAM2020-3184785.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c74/7085384/e40afddbe553/ECAM2020-3184785.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c74/7085384/236b41aa84f1/ECAM2020-3184785.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c74/7085384/8fa670a508ef/ECAM2020-3184785.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c74/7085384/4d05d9866763/ECAM2020-3184785.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c74/7085384/30246fac6907/ECAM2020-3184785.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c74/7085384/e40afddbe553/ECAM2020-3184785.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c74/7085384/236b41aa84f1/ECAM2020-3184785.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c74/7085384/8fa670a508ef/ECAM2020-3184785.005.jpg

相似文献

1
Effect of Moxibustion on Hyperhomocysteinemia and Oxidative Stress Induced by High-Methionine Diet.艾灸对高蛋氨酸饮食诱导的高同型半胱氨酸血症和氧化应激的影响。
Evid Based Complement Alternat Med. 2020 Mar 9;2020:3184785. doi: 10.1155/2020/3184785. eCollection 2020.
2
Folic acid reduces adhesion molecules VCAM-1 expession in aortic of rats with hyperhomocysteinemia.叶酸降低高同型半胱氨酸血症大鼠主动脉中黏附分子血管细胞黏附分子-1（VCAM-1）的表达。
Int J Cardiol. 2006 Jan 13;106(2):285-8. doi: 10.1016/j.ijcard.2005.07.006. Epub 2005 Sep 23.
3
[Effects of moxibustion at 45 ℃ on blood lipoids and serum level of ox-LDL and NO in rats with hyperlipidemia].[45℃艾灸对高脂血症大鼠血脂、氧化型低密度脂蛋白及一氧化氮血清水平的影响]
Zhongguo Zhen Jiu. 2019 Feb 12;39(2):180-4. doi: 10.13703/j.0255-2930.2019.02.018.
4
Homocysteine downregulates gene expression of heme oxygenase-1 in hepatocytes.同型半胱氨酸下调肝细胞中血红素加氧酶-1的基因表达。
Nutr Metab (Lond). 2014 Dec 8;11(1):55. doi: 10.1186/1743-7075-11-55. eCollection 2014.
5
Effects of allicin on hyperhomocysteinemia-induced experimental vascular endothelial dysfunction.大蒜素对高同型半胱氨酸血症诱导的实验性血管内皮功能障碍的影响。
Eur J Pharmacol. 2013 Aug 15;714(1-3):163-9. doi: 10.1016/j.ejphar.2013.05.038. Epub 2013 Jun 20.
6
Human tissue kallikrein-1 protects against the development of erectile dysfunction in a rat model of hyperhomocysteinemia.人组织激肽释放酶-1 可预防高同型半胱氨酸血症大鼠模型勃起功能障碍的发生。
Asian J Androl. 2019 Sep-Oct;21(5):508-515. doi: 10.4103/aja.aja_111_18.
7
Folic acid supplementation inhibits NADPH oxidase-mediated superoxide anion production in the kidney.叶酸补充抑制肾脏中 NADPH 氧化酶介导的超氧阴离子生成。
Am J Physiol Renal Physiol. 2011 Jan;300(1):F189-98. doi: 10.1152/ajprenal.00272.2010. Epub 2010 Oct 27.
8
Disocin prevents postmenopausal atherosclerosis in ovariectomized LDLR-/- mice through a PGC-1α/ERα pathway leading to promotion of autophagy and inhibition of oxidative stress, inflammation and apoptosis.地司琼通过 PGC-1α/ERα 通路预防去卵巢 LDLR-/- 小鼠绝经后动脉粥样硬化，从而促进自噬，抑制氧化应激、炎症和细胞凋亡。
Pharmacol Res. 2019 Oct;148:104414. doi: 10.1016/j.phrs.2019.104414. Epub 2019 Aug 23.
9
Effects of vitamin supplementation and hyperhomocysteinemia on atherosclerosis in apoE-deficient mice.维生素补充和高同型半胱氨酸血症对载脂蛋白E缺乏小鼠动脉粥样硬化的影响。
Atherosclerosis. 2003 Jun;168(2):255-62. doi: 10.1016/s0021-9150(03)00138-2.
10
[Relationship of ox-LDL/LOX-1 and vascular endothelial dysfunction of diet-induced obese immature rats and nicotinic acid's intervention outcomes].[氧化型低密度脂蛋白/凝集素样氧化型低密度脂蛋白受体-1与饮食诱导肥胖未成熟大鼠血管内皮功能障碍及烟酸干预效果的关系]
Zhonghua Yi Xue Za Zhi. 2013 Nov 12;93(42):3388-93.

引用本文的文献

1
Role of hyperhomocysteinemia in atherosclerosis: from bench to bedside.高同型半胱氨酸血症在动脉粥样硬化中的作用：从实验台到临床
Ann Med. 2025 Dec;57(1):2457527. doi: 10.1080/07853890.2025.2457527. Epub 2025 Feb 3.
2
Moxibustion prevents tripterygium glycoside-induced oligoasthenoteratozoospermia in rats via reduced oxidative stress and modulation of the Nrf2/HO-1 signaling pathway.艾灸通过降低氧化应激和调节 Nrf2/HO-1 信号通路预防雷公藤苷致大鼠少弱畸形精子症。
Aging (Albany NY). 2024 Jan 25;16(3):2141-2160. doi: 10.18632/aging.205475.
3
Grain-sized moxibustion at Zusanli (ST36) promotes hepatic autophagy in rats with hyperlipidemia by regulating the ULK1 and TFEB expression through the AMPK/mTOR signaling pathway.

本文引用的文献

1
Moxibustion at CV4 alleviates atherosclerotic lesions through activation of the LXRα/ABCA1 pathway in apolipoprotein-E-deficient mice.艾灸 CV4 通过激活载脂蛋白 E 缺陷型小鼠的 LXRα/ABCA1 通路减轻动脉粥样硬化病变。
Acupunct Med. 2019 Aug;37(4):237-243. doi: 10.1136/acupmed-2016-011317. Epub 2019 May 29.
2
Analytic Approaches for the Treatment of Hyperhomocysteinemia and Its Impact on Vascular Disease.分析方法治疗高同型半胱氨酸血症及其对血管疾病的影响。
Cardiovasc Drugs Ther. 2018 Apr;32(2):233-240. doi: 10.1007/s10557-018-6790-1.
3
Causes of hyperhomocysteinemia and its pathological significance.
足三里（ST36）麦粒灸通过AMPK/mTOR信号通路调节ULK1和TFEB表达促进高脂血症大鼠肝脏自噬。
Heliyon. 2023 Apr 14;9(5):e15316. doi: 10.1016/j.heliyon.2023.e15316. eCollection 2023 May.
4
Moxibustion as adjuvant therapy for preventing bone loss in postmenopausal women: protocol for a randomised controlled trial.艾灸作为辅助治疗预防绝经后妇女骨质流失的随机对照试验方案。
BMJ Open. 2022 Dec 12;12(12):e062677. doi: 10.1136/bmjopen-2022-062677.
5
The Mechanism Study of Moxa Combustion Products on Regulating Vascular Endothelial Function in Atherosclerotic Mice.艾灸燃烧产物对动脉粥样硬化小鼠血管内皮功能调节作用的机制研究
Evid Based Complement Alternat Med. 2022 Oct 3;2022:1303978. doi: 10.1155/2022/1303978. eCollection 2022.
6
Ability of dietary factors to affect homocysteine levels in mice: a review.饮食因素对小鼠同型半胱氨酸水平的影响能力：综述
Nutr Metab (Lond). 2021 Jun 30;18(1):68. doi: 10.1186/s12986-021-00594-9.
高同型半胱氨酸血症的病因及其病理意义。
Arch Pharm Res. 2018 Apr;41(4):372-383. doi: 10.1007/s12272-018-1016-4. Epub 2018 Mar 19.
4
Vascular Remodeling, Oxidative Stress, and Disrupted PPAR Expression in Rats of Long-Term Hyperhomocysteinemia with Metabolic Disturbance.长期高同型半胱氨酸血症伴代谢紊乱大鼠的血管重塑、氧化应激及过氧化物酶体增殖物激活受体表达异常
PPAR Res. 2018 Jan 15;2018:6738703. doi: 10.1155/2018/6738703. eCollection 2018.
5
Homocysteine and Hyperhomocysteinaemia.同型半胱氨酸和高同型半胱氨酸血症。
Curr Med Chem. 2019;26(16):2948-2961. doi: 10.2174/0929867325666180313105949.
6
Elevated Total Homocysteine in All Participants and Plasma Vitamin B12 Concentrations in Women Are Associated With All-Cause and Cardiovascular Mortality in the Very Old: The Newcastle 85+ Study.所有参与者的总同型半胱氨酸升高和女性的血浆维生素 B12 浓度与超高龄人群的全因和心血管死亡率相关：纽卡斯尔 85+研究。
J Gerontol A Biol Sci Med Sci. 2018 Aug 10;73(9):1258-1264. doi: 10.1093/gerona/gly035.
7
Metabolomics analysis reveals an effect of homocysteine on arachidonic acid and linoleic acid metabolism pathway.代谢组学分析揭示了同型半胱氨酸对花生四烯酸和亚油酸代谢途径的影响。
Mol Med Rep. 2018 May;17(5):6261-6268. doi: 10.3892/mmr.2018.8643. Epub 2018 Feb 27.
8
Subchronic methionine load induces oxidative stress and provokes biochemical and histological changes in the rat liver tissue.亚慢性蛋氨酸负荷诱导氧化应激，并引发大鼠肝组织的生化和组织学变化。
Mol Cell Biochem. 2018 Nov;448(1-2):43-50. doi: 10.1007/s11010-018-3311-2. Epub 2018 Feb 8.
9
A Meta-Analysis of Folic Acid in Combination with Anti-Hypertension Drugs in Patients with Hypertension and Hyperhomocysteinemia.叶酸联合抗高血压药物治疗高血压合并高同型半胱氨酸血症患者的Meta分析
Front Pharmacol. 2017 Aug 31;8:585. doi: 10.3389/fphar.2017.00585. eCollection 2017.
10
Efficacy of Folic Acid Therapy in Patients with Hyperhomocysteinemia.叶酸治疗高同型半胱氨酸血症患者的疗效。
J Am Coll Nutr. 2017 Sep-Oct;36(7):528-532. doi: 10.1080/07315724.2017.1330162. Epub 2017 Aug 30.